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Diss Factsheets
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EC number: 201-166-9 | CAS number: 79-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The method, test conditions and design were not sufficiently detailed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
- Year:
- 1 969
- Bibliographic source:
- J. American Ind. Hgy. Assoc., 30 (5):470-476
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list VI
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum, J.S.
- Year:
- 1 962
- Bibliographic source:
- J. American Ind. Hgy. Assoc, 23, 95-107
Materials and methods
- Principles of method if other than guideline:
- The method of Draize used was briefly described in the publication of Smyth et al. (1962). 4 male albino New Zealand albino rabbits/dose were exposed to substance using occlusive dressing and using a logarythmic series of doses.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,2-trichloroethane
- EC Number:
- 201-166-9
- EC Name:
- 1,1,2-trichloroethane
- Cas Number:
- 79-00-5
- Molecular formula:
- C2H3Cl3
- IUPAC Name:
- 1,1,2-trichloroethane
- Details on test material:
- Name of the test substance (as cited in the test report) : 1,1,2-trichloroethane.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals were weighing 2.5 to 3.5 kg.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Fur was removed from the entire trunk by clipping, and dose was retained beneath an impervious plastic film. Animals were immobilised during the 24-h contact period, after which the film is removed and the rabbits are caged for the subsequent 14-day observation period.
- Duration of exposure:
- 24 h
- Doses:
- logarythmic series of doses differing by a factor of 2
- No. of animals per sex per dose:
- 4 males/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the Method of Thompson (1947) using the tables of Weil (1952).
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 380 mg/kg bw
- 95% CL:
- ca. 4 760 - ca. 6 072
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3.73 mL/kg bw
- 95% CL:
- ca. 3.3 - 4.21
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
The LD50 value was reported to be 3.73 mL/kg (corresponding to 5.38 g/kg).
Applicant's summary and conclusion
- Conclusions:
- In this acute dermal toxicity study conducted with mice, the LD50 value was reported to be 5.38 g/kg (3.73 mL/kg).
- Executive summary:
In this acute dermal toxicity study conducted with mice according to Draize's Method, 4 male albino New Zealand albino rabbits/dose were exposed to substance using occlusive dressing and using a logarythmic series of doses.
The LD50 value was reported to be 5.38 g/kg (3.73 mL/kg).
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