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EC number: 274-357-8 | CAS number: 70161-44-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sodium N-(hydroxymethyl)glycinate
- EC Number:
- 274-357-8
- EC Name:
- Sodium N-(hydroxymethyl)glycinate
- Cas Number:
- 70161-44-3
- Molecular formula:
- C3H7NO3.Na
- IUPAC Name:
- sodium N-(hydroxymethyl)glycinate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test materialSuttocide® A (Powder) - Analytical purity:98.45% (Certificate of Analysis included) - Storage: The test article was stored at room temperature and humidity. - Date received01/13/97 - Appearance: White powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Ace Animals, Boyertown, PA, USA- Quarantine period of at least one week- Age at study initiation: 8 to 12 weeks- Weight at study initiation: 240 - 259 grams for males and 234 - 258 grams for females- Housing: 1 /cage in suspended cages. Bedding was placed beneath the cages and changed at least three times/week.- Diet (e.g. ad libitum): Fresh Purina Rat Chow (Diet #5012)- Water (e.g. ad libitum): tap water
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Dosing:Five male and five female rats were exposed to Suttocide® A (Powder), 2.3 mg/I, in an inhalation chamber for four hours. Following exposure the animals were returned to individual housing and observed for 14 days. Chamber Conditions: A 57 liter dynamic glass chamber designed to insure uniform spatial distribution of aerosols and which permitted continuous observation during exposure was used. The chamber was partitioned internally with wire screening into a total of ten non-restraining cubicles. One animal was placed in each cubicle. Chamber temperature and humidity of air entering the chamber were recorded. The airflow through the chamber was calculated to yield at least 1 O to 15 air changes per hour so that adequate oxygen was supplied to the animals. The chamber was maintained at a negative pressure differential to the immediate environment in order to keep the test atmosphere contained. The temperature, humidity, airflow and negative pressure were recorded at approximately thirty minute intervals during the. exposure period. Generation:Suttocide® A (Powder) was fed into a Venturi Dust Generator (lntox) via an augmented screw feeder. During the pretest concentration calibration phase, various screw feeder rates were used until the proper flow rate for generating each concentration was determined. The air flow in the Venturi tube creates suction at the constricted area and the shear flow downstream disperses the particles into aerosol form. The Venturi was powered using pre-filtered compressed air at 20 psi. Nozzle pressure was monitored using a pressure gauge and was recorded initially. The air flow through the chamber was adjusted to insure adequate mixing and uniform concentration of the test article. The chamber atmosphere was exhausted through a tube from the bottom of the chamber, thereby insuring that the aerosol was drawn over the animals' breathing zone. The exhaust air was passed through filters before entering into a rotameter and vacuum pump.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- Actual concentration was determined gravimetrically during exposure to be 2.3 mg/I. Particle size analyses revealed a mass mean aerodynamic diameter of 7.0 with a geometric standard deviation of 2.06.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Type and Frequency of Observations:- In Vivo - Animals were observed at hourly intervals during exposure, at one hour post exposure and once daily thereafter for 14 days for signs of toxicity and pharmacological effects. The animals were observed twice daily for mortality. Body weights were recorded pretest, weekly, at death and at termination in the survivors. - Post Mortem: All animals were examined for gross pathology.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- All animals survived the four hour 2.3 mg/I exposure.
- Clinical signs:
- other: Physical signs of chromodacryorrhea, ocular abnormalities, wetness of the nose/mouth and anogenital area, red staining of the nose/mouth area, coating of fur with test article and abnormal licking were noted during the exposure period. Instances of chromo
- Body weight:
- Body weight changes were normal in 7/1 O animals. Three females lost weight at some time during the observation period.
- Gross pathology:
- Necropsy results were normal.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
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