N-1-naphthylaniline

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Studies of sulfhemoglobin formation by various drugs (3)

Author:

Nomura, A.

Year:

1977

Bibliographic source:

Nippon Yakurigaku Zasshi. 73(7): 793-802

Materials and methods

Principles of method if other than guideline:

Examination of methemoglobin and sulfhemoglobin formation after a single ip administration of the test substance in mice.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

N-1-naphthylaniline

EC Number:

201-983-0

EC Name:

N-1-naphthylaniline

Cas Number:

90-30-2

Molecular formula:

C16H13N

IUPAC Name:

N-phenylnaphthalen-1-amine

Details on test material:

- Name of test material (as cited in study report): N-Phenyl-1-naphthylamine (PNA)
- Analytical purity: no data
- Other: Nakarai Chemicals

Test animals

Species:

mouse

Strain:

other: ddY

Sex:

male

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

CMC (carboxymethyl cellulose)

Doses:

219 mg/kg

No. of animals per sex per dose:

10-15

Control animals:

yes

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 1 other: mM/kg bw

Any other information on results incl. tables

Methemoglobin and sulfhemoglobin formation after a single administration of PNA to mice.

Time after drug administration	N-Phenyl-1-naphthylamine 1mM/kg i.p.
	MHb %	SHb %
0 minutes	/	/
10	4.1±0.6**	0
30	5.7±0.6**	0
90	7.4±0.8**	0
150	7.4±1.0**	0
24 hours	2.4±0.4**	0
48	0.6±0.3	0.1±0.1
72	0.4±0.1	0
96	1.2±0.2**	0