Magnesium bis(dinonylnaphthalenesulphonate)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

December 18, 1980 - January 1, 1981

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: limited report, non GLP, exposure concentrations not clear. The information in the report is limited to the information in the summary.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: FHSLA, 16 CFR 1500

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Magnesium bis(dinonylnaphthalenesulphonate)

EC Number:

248-777-7

EC Name:

Magnesium bis(dinonylnaphthalenesulphonate)

Cas Number:

28015-99-8

Molecular formula:

Mg[C28H43O3S]2

IUPAC Name:

magnesium bis(dinonylnaphthalenesulphonate)

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Taconic Farms
- Age at study initiation: not reported
- Weight at study initiation: Males: 241-300 g; Females: 201-240 g
- Fasting period before study: NA
- Housing: individually
- Diet: Fi sher Rat Chow ad libitum
- Water: ad libitum
- Acclimation period: 31 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

other: oil

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION: no data

VEHICLE: oil
- Concentration of test material in vehicle: 25%

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 4.5 h

Concentrations:

5.1 mg/L (2.6 mg/L as active)

No. of animals per sex per dose:

5 males + 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not indicated (weight at study start and termination)
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs

Statistics:

NA

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 2.6 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

4.5 h

Mortality:

none

Clinical signs:

other: non observed

Body weight:

within expected ranges

Gross pathology:

not performed

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LC50 of the test substance is > 2.6 mg/L.

Executive summary:

Rats (5/sex) were exposed to the test substance at 2.6 mg/L by inhalation. No mortality, clinical signs or effects on body weight were observed. It is therefore concluded that the LC50 is >2.6 mg/L