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EC number: 423-740-1 | CAS number: 10461-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
In short term toxicity study of test chemical 2-cyclohexylidene-2-phenylacetonitrile on Oncorhynchus mykiss in semi static condition for 24, 48, 72 and 96 hrs. with mortality effects 50% lethal concentration (LC50) was found to be as follows:
LC50=2.5 mg/L (24 hrs.)
LC50=2.3 mg/L (48 hrs.)
LC50=1.8 mg/L (72 hrs.)
LC50=0.6 mg/L (96 hrs.)
LC100=> 1 mg/L (96 hrs.)
NOEC<= 0.16 mg/L (96 hrs.)
All these experimental values indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile categorized in aquatic category 1 and 2 as per the CLP criteria.
Supporting study from predicted model also estimate the LC 50 as1.41 mg/l in a 96 hrs.This LC50 value indicate that the test substance 2-cyclohexylidene-2-phenylacetonitrile is toxic to aquatic environment and categorized in Chronic Category 2.
Short-term toxicity to aquatic invertebrates:
In Short term toxicity to aquatic invertebrates Daphnia Magna of test substance 2-cyclohexylidene-2-phenylacetonitrile for 24 and 48 hrs.the effect concenttration (EC50) was found as followed:
EC50=3.5 mg/L (24 h)
EC50=2.3 mg/L (48 h)
EC100=> 3 mg/L (48 h)
NOEC=1.4 mg/L (48 h)
All experimental values indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile was categorized in aquatic category 2 as per the CLP criteria.
Toxicity to aquatic algae and cyanobacteria:
In aquatic algae toxicity study for 72 hrs. on Scenedesmus capricornutum species the effective concentration was found to as followed:
EC50=0.86 mg/L (72 h) at biomass effect
EC50=1.96 mg/L (72 h) at growth rate effect
NOEC=0.5 mg/L(72 h) at growth rate effect
NOEC=0.5 mg/L(72 h) at biomass effect
All experimental values indicate that the test substance2-cyclohexylidene-2-phenylacetonitrile was categorized in aquatic category 1 and 2 as per the CLP criteria.
Supporting study from predicted model (ECOSAR v1.1 )indicate that the Effect concentration (EC50) for the test compound 2-cyclohexylidene-2-phenylacetonitrile in a 96h study using green algae is 1.771 mg/L.
This EC50 values indicate that the test substance is toxic to aquatic environment and catogerized in aquatic chronic 2 as per the CLP criteria.
Toxicity to microorganisms:
In micro organism toxicity study by OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) for 3 hrs. resulted as followed:
IC50=> 3159 mg/L (3 h)
NOEC=> 3159 mg/L (3h)
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