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Diss Factsheets
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EC number: 206-117-5 | CAS number: 302-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
At an initial concentration of 88 and 84.8 uM hydrolysis rate constants for chloral hydrate was determined to be 1.0X10-3/hr and 1.8X10-3/hr using MOPS buffer and carbonate buffers respectively in the presence of carbonate green rust; GR(CO32-).
Chloral hydrate were transformed via parallel pathways of hydrolysis and sequential hydrogenolysis in the presence of GR(CO32-).
Chloral hydarte was degraded to TCM (Tricholormethane) via hydrolysis (31%) and to DCAh (Dichloro acetaldehyde hydrate) via hydrogenolysis (69%).
Additional information
Hydrolysis:
The study was performed to investigate the kinetics and pathways of the degradation of selected halogenated DBPs (Disinfection byproducts), i.e. cholral hydrate in the presence of carbonate green rust; GR(CO32-). DBP degradation experiments were carried out in 123 mL serum bottles containing a 2.4 g/L GR(CO32-) suspension buffered at pH 7.5 with Ar-sparged 25 mM MOPS buffer or 50 mM carbonate buffer at 22±3 °C. All batch experiments were conducted in duplicate. The overall loss and individual hydrolysis and reductive dehalogenation pseudo-first-order rate constants of the DBPs were determined by fitting the experimental data using Scientist for Windows (v. 2.01, Micromath Research).
At an initial concentration of 88 and 84.8 uM hydrolysis rate constants for chloral hydrate was determined to be 1.0X10-3/hr and 1.8X10-3/hr using MOPS buffer and carbonate buffers respectively in the presence of GR(CO32-). Chloral hydrate were transformed via parallel pathways of hydrolysis and sequential hydrogenolysis in the presence of GR(CO32-). Chloral hydarte was degraded to TCM (Tricholormethane) via hydrolysis (31%) and to DCAh (Dichloro acetaldehyde hydrate) via hydrogenolysis (69%).
Thus, from above study it can be considered that the substance chloral hydrate is very slowly hydrolysable.
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