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EC number: 202-658-6 | CAS number: 98-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from J-CHECK and OECD SIDS
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Twenty-eight-day Repeat Dose Oral Toxicity Test of 2-Amino-5- methylbenzenesulfonic acid in Rats
- Author:
- Ministry of Health & Welfare, Japan
- Year:
- 1 996
- Bibliographic source:
- Ministry of Health & Welfare, Japan (1996a): Toxicity Testing Reports of Environmental Chemicals, vol.4 p99-106
- Reference Type:
- secondary source
- Title:
- Assessment Report for 4-AMINOTOLUENE-3-SULFONIC ACID CAS N°: 88-44-8
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 16 Paris, 27-30 May 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: No data
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of 4-aminotoluene-3-sulphonic acid to rat
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- Molecular formula:
- C7H9NO3S
- IUPAC Name:
- 2-amino-5-methylbenzenesulfonic acid
- Details on test material:
- - Name of test material (IUPAC name): 2-Amino-5-Methylbenzenesulfonic Acid
- Common name: p-Toluidine-m-sulfonic acid
- Molecular formula: C7H9NO3S
- Molecular weight: 187.2181 g/mol
- Smiles notation: Cc1ccc(c(c1)S(=O)(=O)O)N
- InChl: 1S/C7H9NO3S/c1-5-2-3-6(8)7(4-5)12(9,10)11/h2-4H,8H2,1H3,(H,9,10,11)
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-amino-5-methylbenzenesulfonic acid
- Molecular formula (if other than submission substance): C7H9NO3S
- Molecular weight (if other than submission substance): 187.2181 g/mole
- Substance type: Organic
- Physical state:
Purity: 99.30 wt%
- Impurities (identity and concentrations):0.70 %
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source:Charles River Japan Inc
- Age at study initiation: 5 week old male
- Weight at study initiation: 168183 g, female 138 162 g
- Fasting period before study:
- Housing: Rats were individually housed in a wire mesh cage
- Diet (e.g. ad libitum): solid feed, ad libitum
- Water (e.g. ad libitum): water ad libitum
- Acclimation period:No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C):22 ± 3 ° C
- Humidity (%):55 ± 10%
- Air changes (per hr): ventilation frequency of 10 times or more / hour
- Photoperiod (hrs dark / hrs light): 12 hours of lighting (6 to 18 o'clock
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: sesame oil, 0.5mL/100g bw
- Details on oral exposure:
- No data
- Doses:
- 12000 mg / kg bw /day
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 12 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality obsserved
- Mortality:
- 50 % mortality obsserved at 12000 mg / kg in treated rats.
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LD50 was considered to be 12000 mg/kg bw when rats were orally exposed with 4-aminotoluene-3-sulphonic acid.
- Executive summary:
In acute oral toxicity study, Sprague-Dawley rats were treated with 4-aminotoluene-3-sulphonic acid in the concentration of 12000 mg /kg bw orally by gavage . 50 % mortality obsserved at 12000 mg / kg in treated rats. Therefore, LD50 was considered to be 12000 mg/kg bw when rats were orally exposed with 4-aminotoluene-3-sulphonic acid.
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