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EC number: 250-333-2 | CAS number: 30772-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 May 1991 - 21 May 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability 1 is assigned because the study conducted according to OECD TG 404 and in compliance with GLP, without deviations that influence the quality of the results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (1981)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- EC Number:
- 250-333-2
- EC Name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- Cas Number:
- 30772-79-3
- Molecular formula:
- C11H16O
- IUPAC Name:
- (1R,2S,3S,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-3-carbaldehyde; bis((1R,2S,4R,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-4-carbaldehyde)
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Formyltricyclodecan
- Storage condition of test material: at ambient air temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Source: Harald Schriever, Kaninchenfarm, Neuendamm 88, D-2740 Bremervörde
- Weight at study initiation: 2-3 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 30-70
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Adjacent area of the untreated skin of each animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied (volume): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 5 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorsal, approximately 6 cm²
- Type of wrap if used: semi-occlusive dressing of Kosmoplast, held in place by non-irritating tape Elastoplast and Stülpa wrapped around the whole trunk of the animal.
REMOVAL OF TEST SUBSTANCE
- Washing: Residual samples were carefully washed off with water or an appropriate solvent
- Time after start of exposure: 4 hours
OBSERVATIONS
- Clinical signs for erythema and oedema: 30-60 min, 24 hours, 48 hours and 72 hours after patch removal and thereafter once daily up to day 5. Observations were extended to determine reversibility or irreversibility of the lesions.
SCORING SYSTEM
The irritation was assessed according to the numerical scoring system according to OECD 404 (1981).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours (mean)
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritant / corrosive response data:
- Animals showed slight signs of erythema within 3 days after treatment. No signs of oedema were observed, apart from a very slight oedema in one animal up to 60 minutes after treatment. The observed findings were reversible within 4 days.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a skin irritation study with 3 rabbits, performed according to OECD guideline 404, the mean erythema and oedema scores for all animals were well below the limit mentioned in the EU classification criteria. Based on these results, the substance is not considered to be irritating to skin.
- Executive summary:
The substance was tested in a skin irritation test in 3 rabbits in accordance with OECD TG 404 test guideline. The animals showed slight signs of erythema within 3 days after treatment. No signs of oedema were observed, apart from a very slight oedema in one animal up to 60 minutes after treatment. The observed findings were reversible within 4 days. The mean value for erythema and oedema from gradings at 24, 48 and 72 hours after patch removal was well below the limit mentioned in the EU classification criteria (which is 2.3). No corrosive effect was observed. The irritation was fully reversible within 4 days after treatment. Based on these results, the substance is not considered to be irritating to skin.
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