3,4,5,6-tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

Density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04/05/2016 - 04/05/2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of test item 3,4,5,6-tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid (CAS No. 18472-87-2) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

pour and tap (for solids)

Type:

pour density

Density:

0.742 g/cm³

Temp.:

24.5 °C

Remarks on result:

other: at 972.5 hPa atmospheric pressure

Type:

tap density

Density:

0.871 g/cm³

Temp.:

24.5 °C

Remarks on result:

other: at 972.5 hPa atmospheric pressure

CALCULATIONS:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1^stReading	2^ndReading
Method	Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	24 °C	25 °C
Atmospheric pressure (in hPa)	-	971.5 hPa	973.6 hPa
Weight of test item(m)		20 g	20 g
Volume of measuring cylinder; readability in g		250 ml;2ml	250 ml;2ml
Volume of test item without tapping (V)		26 ml	28 ml
Volume of test item after tapping ( V1)	After 10 tapping	24 ml	22 ml
	After 50 tapping	24 ml	22 ml
	After 100 tapping	----	-------
	After 250 tapping	------	------
	After 500 tapping	----------	------.
	After 750 Tapping	-----	---------

CALCULATIONS:

Parameters	Details	Calculated values		Average Density
		1^stCalculation	2^ndCalculation
Pour Density of test Item (g/cm^3)	= m     V	20/26 = 0.7692 g/cm^3	20/28= 0.7142 g/cm^3	0.7417 g/cm^3
Tap density of test Item (g/cm^3)	= m     V1	20/24 = 0.8333 g/cm^3	20/22 = 0.9090 g/cm^3	0.8711 g/cm^3

Conclusions:

The mean density of test item was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus . The mean pour density and tapped density of the test item was determined to be 0.7417 g/cm3 and 0.8711 g/cm3 at 24.5 deg C and 972.5 hPa.

Executive summary:

The density of test item  was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was determined to be 0.7417 g/cm3and 0.8711 g/cm3 at 24.5oC and 972.5 hPa.

Description of key information

The density of test item  was determined following OECD Guideline 109 and according to the Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus . The mean pour density and tapped density of the test item was determined to be 0.7417 g/cm3 and 0.8711 g/cm3 at 24.5 degC and 972.5 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.871

Additional information

The density of test item  was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014.The mean pour density and tapped density of the test item was determined to be0.7417 g/cm3and 0.8711 g/cm3at 24.5oC and 972.5 hPa.