[[4-[[2-(4-cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

pour density and tapped density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28-02-2018 – 28-02-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of Test item was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

pycnometer method

Specific details on test material used for the study:

- Name of test material : Disperse Yellow 201
- IUPAC name : (4-{[2-(4-cyclohexylphenoxy)ethyl](ethyl)amino}-2-methylbenzylidene)malononitrile / Solvent Yellow 179
- Molecular formula): C27H31N3O
- Molecular weight :413.562 g/mol
- Smiles notation : N#C\C(C#N)=C/c1c(cc(N(CCOc2ccc(cc2)C2CCCCC2)CC)cc1)C
- InChl: 1S/C27H31N3O/c1-3-30(26-12-9-25(21(2)17-26)18-22(19-28)20-29)15-16-31-27-13-10-24(11-14-27)23-7-5-4-6-8-23/h9-14,17-18,23H,3-8,15-16H2,1-2H3
- Substance type:Organic
- Physical state:Solid

Key result

Type:

pour density

Density:

0.69 g/cm³

Temp.:

31 °C

Remarks on result:

other: at 976.8 hPa pressure

Key result

Type:

tap density

Density:

0.742 g/cm³

Temp.:

31 °C

Remarks on result:

other: at 976.8 hPa pressure

TEST ITEM DESCRIPTION AND RESULTS

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1st	2ndReading
		Reading
Method	Test methods: Pour density
	and tapped density of
	powders” recommended in
	The International
	Pharmacopoeia, Fourth
	Edition, 2014
Principle of method	Pour Density:It is the ratio
	ofknownweight oftest item
	and its volume in graduated
	glass cylinder.
	Tap Density:It is the
	difference between the
	volume of test item
	measured before & after
	tapping in the graduated
	glass cylinder.
Test temperature (°C)	-	30°C	32°C
Atmospheric	-	978.4	975.3
pressure (in hPa)
Weight of test		20	20
item(m)
Volume of measuring		250 ml;2 ml	25 ml;2 ml
cylinder; readability
in g
Volume of test item		30	28
without tapping (V)
Volume of test item	After 10 tapping	28	26
after tapping ( V1)
	After 50 tapping	28	26
	After 100 tapping	-	-
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 Tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

CALCULATIONS:

 FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	=mV	0.6666	0.7142	0.6904
Tap density of test Item (g/cm³)	=mV1	0.7142	0.7692	0.7417

 

Conclusions:

The mean pour density and tapped density of test chemical was determine to be 0.6904 g/cm³ and 0.7417 g/cm³ at 31 °C and 976.8 hPa.

Executive summary:

The density of test item was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was determine to be 0.6904 g/cm³ and 0.7417 g/cm³ at 31 °C and 976.8 hPa.

Description of key information

The mean pour density and tapped density of test chemical was determine to be 0.6904 g/cm³ and 0.7417 g/cm³ at 31 °C and 976.8 hPa.

Additional information

The density of test item was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was determine to be 0.6904 g/cm³ and 0.7417 g/cm³ at 31 °C and 976.8 hPa.