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EC number: 221-337-1 | CAS number: 3069-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
An Ames test is available with N-[3-(methoxydimethylsilyl)propyl]ethylenediamine (CAS 3069-33-8).
The mutagenicity of N-[3-(methoxydimethylsilyl)propyl]ethylenediamine in bacteria was assessed in a study performed according to OECD Guideline 471 with Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102 (LPT, 2002). The tester strains were treated using the plate incorporation and the preincubation method both with and without S9-mix. The concentrations tested were 10 - 1000 and 3.16 - 316 µg/plate for the plate incorporation and preincubation test, respectively. Results achieved with vehicle (DMSO) and positive controls were valid. No genotoxicity was observed in the presence and absence of metabolic activation. No precipitation was observed up to the highest dose tested. Cytotoxicity (defined as reduction of colonies by more than 50% and/or by a scarce background lawn) was observed in all strains at 1000 (plate incorporation) or 316 (preincubation) µg/plate. In the plate incorporation test cytotoxicity was observed at lower concentrations in TA 102 (-S9: 100 µg/plate; +S9: 316 µg/plate), TA 1535 (-S9: 316 µg/plate), TA 1537 (-S9: 316 µg/plate; +S9: 316 µg/plate). In the preincubation test cytotoxicity was observed at lower concentrations in TA 98 (-S9: 100 µg/plate), TA 102 (-S9: 100 µg/plate; +S9: 316 µg/plate), TA 1535 (-S9: 100 µg/plate; +S9: 316 µg/plate), TA 1537 (+S9: 316 µg/plate).
In conclusion, N-[3-(methoxydimethylsilyl)propyl]ethylenediamine did not induce mutations in bacteria under the test conditions applied.
Justification for selection of genetic toxicity endpoint
The available in vitro data fulfil the standard requirements given in Annex VII of Regulation (EC) 1272/2008. Therefore the mutagenicity study was chosen under "Endpoint selection" in accordance with ECHA, Practical guide 14, Version 1, 2012.
Short description of key information:
Mutagenicity in bacteria (OECD 471, Ames): S. typhimurium strains: TA 98, TA 100, TA 102, TA 1535 and TA 1537: negative with and without metabolic activation
Mutagenicity in mammalian cells: no data
Clastogenicity in mammalian cells: no data
Mutagenicity/clastogenicity in vivo: no data
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available in vitro data are reliable and suitable for classification and fulfil the standard requirements given in Annex VII of Regulation (EC) 1272/2008. Based on the available data, there is no indication that the substance induces genetic toxicity. Nevertheless, no final decision on classification for genetic toxicity according to Regulation (EC) 1272/2008 or Directive 67/548/EEC can be made, as no information on mutagenicity and clastogenicity in mammalian cells/in vivo is available.
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