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EC number: 235-970-6 | CAS number: 13074-65-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-04-13 to 1982-07-12
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline. Limited substance information (e.g. purity) and reversibility of effects not fully assessed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In the preliminary test, albino Wistar rats are administered the test substance to intact, uncovered, clipped dorsal skin, undiluted and at concentrations of 30% and 10%. Observations of the treatment site were made for up to 72 hours. In a subsequent phototoxicity test, a 30% solution of the test substance was applied, with and without a period of exposure to light.
- GLP compliance:
- not specified
- Remarks:
- The study pre-dates the introduction of GLP in the United Kingdom
Test material
- Reference substance name:
- 2-n-hexyl cyclopentanone
- IUPAC Name:
- 2-n-hexyl cyclopentanone
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 2-n-hexyl cyclopentanone
- Substance type: no data.
- Physical state: no data.
- Analytical purity: no data.
- Impurities (identity and concentrations): no data.
- Composition of test material, percentage of components: no data.
- Isomers composition: no data.
- Purity test date: no data.
- Lot/batch No.: 5.12947T1
- Expiration date of the lot/batch: no data.
- Stability under test conditions: no data.
- Storage condition of test material: refrigerated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: "Colworth colony".
- Age at study initiation: no more than 29 days.
- Weight at study initiation: at least 35 g (at weaning).
- Housing: individually, in cages with wire mesh floors.
- Diet (e.g. ad libitum): ad libitum access to pelleted commercial rat diet.
- Water (e.g. ad libitum): ad libitum.
- Acclimation period: no data.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data.
- Humidity (%): no data.
- Air changes (per hr): no data.
- Photoperiod (hrs dark / hrs light): no data.
IN-LIFE DATES: no data.
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: Ethanol
- Controls:
- other: PRELIMINARY IRRITATION TEST: yes, concurrent vehicle; PHOTOTOXICITY TEST: yes, concurrent no exposure to light.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL.
- Concentration (if solution): PRELIMINARY IRRITATION TEST: 10, 30 and 100%; PHOTOTOXICITY TEST: 30%
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.1 mL.
- Concentration (if solution): not applicable.
- Lot/batch no. (if required): no data.
- Purity: no data. - Duration of treatment / exposure:
- Up to 72 hours. The methods detailed in the study report do not mention any washing or other removal of the test substance in the preliminary irritation test.
- Observation period:
- Up to 72 hours.
- Number of animals:
- PRELIMINARY IRRITATION TEST: 5 rats/concentration.
PHOTOTOXICITY TEST: 10 rats/group. - Details on study design:
- TEST SITE
- Area of exposure: "spread across the clipped dorsum of each rat".
- % coverage: no data.
- Type of wrap if used: not applicable.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not washed.
- Time after start of exposure: not applicable.
SCORING SYSTEM: treatment sites were assessed for erythema, oedema, cracking, scaling, dryness, haemorrhage, ulceration, scabbing and exudation on a 9-point scale. 0 = absent; 1 = very slight; 2 = slight; 3 = slight to distinct; 4 = distinct; 5 = distinct to well developed; 6 = well developed; 7 = well developed to severe; 8 = severe.
LIMITATIONS: The reversibility of the graded effects was not assessed in this study; scores were only recorded up to 72 hours after administration.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 3.7
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 1.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 3.3
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 1.7
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2.7
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 1.9
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Mean of 24, 48 and 72 hour gradings.
- Score:
- 2.7
- Max. score:
- 8
- Reversibility:
- no data
- Remarks on result:
- other: Result of preliminary irritation test, group A (undiluted test substance).
- Irritant / corrosive response data:
- In the preliminary irritation test, using undiluted test material, individual erythema scores (taken as the mean of the 24, 48 and 72 hour gradings) ranged from 1.3 to 2.3. Individual oedema scores ranged from 2.3 to 3.7. In all cases, scores were reported out of a maximum of 8. Based on the descriptions of each value in the scoring system, these results are indicative of a slight irritant.
The investigators considered the 30% solution (in ethanol) to be "minimally irritant" for the purposes of a dose to be carried forward into the phototoxicty study.
Any other information on results incl. tables
Other effects graded in study report for preliminary irritation test, group A (undiluted test substance):
Animal | Cracking score (max. 8) | Scaling score (max. 8) | Scabbing score (max. 8) |
Animal #1 | 3 | 2.3 | 0.7 |
Animal #2 | 1.7 | 2.3 | 0.3 |
Animal #3 | 2.3 | 3 | 0.3 |
Animal #4 | 3 | 3 | 1 |
Animal #5 | 2.7 | 2.7 | 1 |
Mean | 2.5 | 2.7 | 0.7 |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: description of scoring system in study report.
- Conclusions:
- An application (0.1 mL) of undiluted Jasmatone (2-n-hexyl cyclopentanone) was found to be slightly irritating to the skin of rats..
- Executive summary:
In an in vivo study, conducted prior to the introduction of GLP or the applicable OECD test guideline, undiluted Jasmatone (2 -n-hexyl cyclopentanone, 0.1 mL) was applied to the skin of 5 Wistar rats. No details on length of application were reported, but the treatment site was apparently left uncovered during the 72 hour observation period.
Mean erythema and oedema scores of 1.9 and 3 (out of 8) were reported for the treated group, expressed as a mean of the 24, 48 and 72 hour gradings. According to the scoring system in the report, this represented a slight irritant. Other effects reported included cracking (mean score 2.5/8), scaling (2.7/8) and scabbing (0.7/8) of the skin. Reversibility of effects not fully assessed.
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