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Diss Factsheets
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EC number: 943-210-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 21, 1978 to May 5, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 4-Hour Acute Inhalation Toxicity in Rats in Accordance With the Regulations as Defined in the Protocol Submitted by Ciba-Geigy. Ten laboratory rats (5 males & 5 females) are exposed in a 40 liters (36 x 36 x 31 cm) glass exposure chamber, to the test substance via the inhalation route at an atmospheric concentration of 2.34 ± 0.26 mg/l for 4 hours.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- tetrasodium 15-[(Z)-2-{4-[(E)-2-{4-[(E)-2-{2,5-dimethyl-4-[(E)-2-(4-sulfophenyl)diazen-1-yl]phenyl}diazen-1-yl]-2-sulfophenyl}ethenyl]-3-sulfophenyl}diazen-1-yl]-10,12-dioxa-2,3-diaza-11-cupratricyclo[11.4.0.0^{4,9}]heptadeca-1(17),2,4,6,8,13,15-heptaene-6-sulfonate
- EC Number:
- 943-210-6
- Molecular formula:
- Not applicable. UVCB Substance
- IUPAC Name:
- tetrasodium 15-[(Z)-2-{4-[(E)-2-{4-[(E)-2-{2,5-dimethyl-4-[(E)-2-(4-sulfophenyl)diazen-1-yl]phenyl}diazen-1-yl]-2-sulfophenyl}ethenyl]-3-sulfophenyl}diazen-1-yl]-10,12-dioxa-2,3-diaza-11-cupratricyclo[11.4.0.0^{4,9}]heptadeca-1(17),2,4,6,8,13,15-heptaene-6-sulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: no data- Weight at study initiation: 245 - 324 g- Housing: The animals were housed, individually, in suspended wire bottom cages- Diet: ad libitum- Water: ad libitumENVIRONMENTAL CONDITIONS- Temperature (°C): 23 ± 1 °C- Humidity (%): 45-55 %- Photoperiod (hrs dark / hrs light): 12 hours cycle dark/light
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTIONThis test was conducted in a 40 l (36 x 36 x 31 cm) glass exposure chamber. The sides and the bottom of the chamber had centred holes (3-4 cm in diameter) to allow access to the chamber for testing and exhaust of the atmosphere. The port in the bottom of the chamber was centred over a 10 cm hole in a wooden platform. A funnel (8.5 cm in diameter) was brought from the underside of the platform through the hole and centred on the port in the bottom of the chamber. Dynamic air flow within the chamber was maintained by connecting the funnel to a vacuum pump for continuous changing of the chamber atmosphere.- Exposure chamber volume: 40 l (36 x 36 x 31 cm) glass exposure chamber.- Source and rate of air: Dynamic air flow within the chamber was maintained by connecting the funnel to a vacuum pump for continuous changing of the chamber atmosphere.- System of generating particulates/aerosols: The test substance was generated as a dust using a 3-neck, round-bottom, 250 ml Pyrex flask. A stirring mechanism was placed through the center neck of the flask and an air line through one of the side necks. The third neck was connected by a glass elbow (which had an air vent to allow flushing) to the chamber. The dust was introduced into the chamber through a side port. A piece of rubber was taped over the outer area around the hole and a vertical slit made in the rubber to allow the entrance of the glass elbow from the dust generator. Constant flow of material was maintained by a calibrated flowmeter connected between the air line and the generating apparatus. In all instances, the air flow was maintained at or above 0.5 liter of air per minute per rat. - Method of particle size determination: Particle size determinations were made using a Cascade Impactor- Treatment of exhaust air: filter holder was attached to a vacuum pump which was regulated to exhaust 1.0 liter of air per minute from the chamber through the filterTEST ATMOSPHERE- Brief description of analytical method used: Measurement of the atmospheric concentration of test substance in the chamber was achieved using a Gelman Model 1235 stainless steel filter holder containing a pre-weighed glass fiber filter (Gelman type AE-47 mm).
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 2.34 ± 0.26 mg/l
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: 4 times for clinical signs. All animals were weighed prior to the initiation of the exposure and on days 1, 7 and 14 following exposure. - Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 2.34 mg/L air (analytical)
- Based on:
- test mat.
- 95% CL:
- ca. 0.26
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 2.106 mg/L air (analytical)
- Based on:
- act. ingr.
- 95% CL:
- ca. 0.26
- Exp. duration:
- 4 h
- Mortality:
- no mortality observed
- Clinical signs:
- other: abnormal respiration was noted during the first 2 hours post-exposure. This condition was not noted 4 hours post-exposure and animals appeared normal for the remainder of the observation period.
- Body weight:
- Eight animals (4 males and 4 females) showed slight weight losses on day one; however, all animals were gaining weight normally for the remainder of the observation period.
- Gross pathology:
- The results of the gross pathological examinations showed that organs of all rats were within normal limits.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- not classified according to CLP Regulation (EC n. 1272/2008)
- Conclusions:
- The test substance shows no adverse effect at concentration of 2.34 mg/l (2.10 mg/l based on active ingredient).
- Executive summary:
The substance has been tested for acute toxicity via inhalation route. Ten laboratory rats (5 males and 5 females) initially weighing between 245 and 324 grams, when exposed to test substance via the inhalation route at an atmospheric concentration of 2.34 ± 0.26 mg/l for 4 hours, exhibited no observable adverse clinical signs during the exposure. Abnormal respiration was observed in all animals during the first 2 hours post-exposure. However, all animals appeared normal when observed 4 hours after the exposure. No abnormalities were noted during the 14-day post-exposure period, therefore the LC0 is 2.34 mg/l (2.10 mg/l based on active ingredient). The concentration stated above was the maximum attainable aerosol concentration of the test material under the experimental conditions. The average mass median particle diameter was 8.04 ± 1.62 µm. Gross pathological observations showed organs of all animals to be within normal limits.
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