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EC number: 440-550-2 | CAS number: 244021-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD- and EEC-Guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Details on test material:
- Identification: TKA 40270 (CGPS 345)
Batch Number: Lot 02243FC7, Op. 1/07
Purity: Confidential Information (see Analytical Certificate, study no. 38291-1)
Appearance: Liquid, Colorless to yellow
Expiry Date: October 01, 2012
Storage Conditions: At room temperature at about 20 °C. Storage at under 18 °C may lead to partial solidification. To reliquify, heat content to 25-35 °C. Protect from light.
As the test item is light sensitive, all test item handling was performed under red light.
Constituent 1
- Radiolabelling:
- not specified
Study design
- Test temperature:
- RT
HPLC method
- Details on study design: HPLC method:
- Apparatus: Merck-Hitachi autosampler L-7200
Merck pump L-6200
Merck UV/VIS detector L-4200
Column: LiChrospher 100 CN, particle size 5 µm, 250 mm x 4 mm
Mobile Phase: Water / methanol (45:55; v/v); pH 6.8
Detection: Test item: 218 nm
Reference items: 218 nm
Sodium nitrate: 218 nm
Temperature: RT °C
Injection Volume: 10 µL
Flow: 1.0 mL/min
Run Time: 30 minutes
Retention Times: 7.51
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 115.02 µg/mL
- Sampling interval: injected three times.
- Sample storage before analysis: No data
- Details on test conditions:
- 38.34 mg TKA 40270 (CGPS 345) was dissolved in acetonitrile (100 mL) to prepare a stock
solution of 383.4 µg/mL. The stock solution (3 mL) was diluted with a solvent mixture of
methanol and water (55:45; v/v) to 10 mL to obtain a test solution of 115.02 µg/mL. The pH
value of the test item solution was determined to be 6.8. This test item solution was injected
three times.
Duration of adsorption equilibration
- Sample No.:
- #3
- Duration:
- 7.53 min
- Initial conc. measured:
- 11.5 mg/kg sludge solids
- pH:
- 6.8
- Temp.:
- 22 °C
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- 14 824
- Type:
- log Koc
- Value:
- 4.2
Results: HPLC method
- Details on results (HPLC method):
- Stock solutions of the reference items were prepared as described:
10.94 mg of acetanilide, 10.89 mg of isoproturon, 10.15 mg of linuron, 11.37 mg of pyrazophos,
11.17 mg of diclofop-methyl and 10.49 mg of 2,4-DDT were each dissolved in 10 mL of
methanol.
A combined reference solution was prepared by transferring 500 µL of each stock solution
(acetanilide, isoproturon, linuron, pyrazophos, diclofop-methyl and 2,4-DDT) into one
volumetric flask and diluting to a volume of 5 mL with a solvent mixture of methanol and water
(55:45; v/v). This reference solution was injected six times.
Sodium nitrate (10.93 mg) was dissolved in 10 mL of methanol to obtain a stock solution. The
stock solution (100 µL) was diluted to 1 mL with a solvent mixture of methanol and water
(55:45; v/v). This sodium nitrate solution was injected six times for the determination of the dead
time of the HPLC system.
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Not applicable.
- Recovery of test material:
- Not applicable
- Concentration of test substance at end of adsorption equilibration period:
- Not applicable
- Concentration of test substance at end of desorption equilibration period:
- Not applicable
- Details on results (Batch equilibrium method):
- Not applicable
- Statistics:
- Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log of the adsorption coefficient (KOC) of TKA 40270 (CGPS 345) was estimated to be
log KOC 4.2 which is equal to a KOC value of 14824 using the HPLC method. This value indicates that TKA 40270 (CGPS 345) will be adsorbed by
organic carbon in soil. TKA 40270 (CGPS 345) can be classified to be immobile. - Executive summary:
The test item solution was injected three times and the combined reference solution was injected six times. The log KOC of the test item was calculated using a regression curve (log k' vs. log KOC) and was found to be 4.2, which is equal to a KOC value of 14824. In the present study the reference items covered the range of log KOC 1.25 to log KOC 5.63.
The chromatography of the test item resulted in one sharp main peak with a well-defined and reproducible retention time. Based on the chromatographic data, TKA 40270 (CGPS 345) was considered to be stable during the test procedure.
The capacity factor (k') was calculated for each reference item using the retention times. Log KOC was plotted versus log k' for each component to obtain a regression curve. The tabulated values represent rounded mean results, which were obtained by calculation using the exact raw data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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