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Diss Factsheets
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EC number: 221-877-8 | CAS number: 3266-23-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restriction
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-epoxybutane
- EC Number:
- 221-877-8
- EC Name:
- 2,3-epoxybutane
- Cas Number:
- 3266-23-7
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2,3-dimethyloxirane
- Details on test material:
- - Name of test material (as cited in study report): N-Butylenoxid-2.3
- Substance-No.: 81-356
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach
- Age at study initiation: ca. 12 weeks
- Weight at study initiation: mean 280 g (males), 230 g (females)
- Fasting period before study: 16 hours prior to dosing, but water ad libitum
- Housing: 5 per cage in V-II-A-STAHL-wire mesh cages, type DK-III (Becker & C., Castrop-Rauxel)
- Diet (e.g. ad libitum): SSNIFF R; SSNIFF, Versuchstierdiaeten, Soest
- Water (e.g. ad libitum): VE-water on working days; tap water on weekends; ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 45 - 75
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10.0, 14.7, 21.5, 31.6%
- Amount of vehicle (if gavage):10 ml/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw - Doses:
- 1000, 1470, 2150, 3160 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: <15 min, 15 min, 30 min, 1 h, 2 h, 4 h and 5 h after dosing. Then daily on weekdays. Twice daily on weekdays and once daily on weekends check for mortality. Weighing on days prior to dosing and on days 4, 7 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality, body weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 150 mg/kg bw
- Mortality:
- 3160 mg/kg bw: 5/5 males and 2/5 females within 24 hours
2150 mg/kg bw: 3/5 males and 3/5 females within 24 hours
1470, 1000 mg/kg bw: no mortality - Clinical signs:
- other: Clinical signs included dyspnoe, apathy, staggering, skin redness and reduced state in males and females at all doses. At highest dose excicossis, abnormal position and atonia was also observed.
- Gross pathology:
- - Sacrified animals: nothing abnormal detected
- Moribund animals:
2150 mg/kg bw: congestion, pronounced hydrothorax, pronounced hyperemia with edema in lungs, brownish liver, brighten kidneys
3160 mg/kg bw: pronounced hydrothorax, pronounced hyperemia with edema in lungs, partial degeneration
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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