Registration Dossier
Registration Dossier
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EC number: 252-488-1 | CAS number: 35285-69-9
Endpoint summary
Administrative data
Description of key information
Oral (OECD 401), rat: > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2), and is thus sufficient to fulfill the standard information requirements set out in Annex VII, 8.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The potential acute oral toxicity of sodium 4-propoxycarbonylphenoxide (CAS 35285-69-9) was assessed in a study performed according to a protocol similar to OECD 401 (Bayer, 1982). 10 rats/sex were administered 1000 (only in females), 3100 and 5000 mg/kg bw of the test substance by gavage. No mortality occurred in the 1000 mg/kg bw group. In the 3100 mg/kg bw group, 1/10 females died during the first day after application of the test substance. In the 5000 mg/kg bw group, 2/10 males and 5/10 females were found dead during the first 3 days after application of the test substance. Clinical signs were observed at 3100 mg/kg bw (females) and higher or at 5000 mg/kg bw (males). The general condition of all animals was decreased. Signs of sedation and anaesthesia were observed. These symptoms were (almost) fully reversible within 7 days (females) or 2 days (males). Necropsy in surviving animals on random basis revealed no substance related findings. Based on the results of the conducted study, the oral LD50 value is considered to be > 5000 mg/kg bw .
Justification for classification or non-classification
The available data on acute oral toxicity do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
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