Registration Dossier
Registration Dossier
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EC number: 926-197-1 | CAS number: -
Explosiveness
Administrative data
- Endpoint:
- explosiveness, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 August 2015-17 November 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant study in accordance with UN-MTC Appendix 6 and OPPTS 830.6316.
Data source
Referenceopen allclose all
- Reference Type:
- other: study amendment
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Appendix 6 "Screening procedures", 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Part I Section 13 “Test Series 3”, 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.6316 (Explodability)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
- EC Number:
- 926-197-1
- Cas Number:
- 2561176-48-3
- Molecular formula:
- C20 H15 N3 O9
- IUPAC Name:
- 5-[(S)-4-Carboxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyrylamino]-2-nitro-benzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name (as cited in study report): P-Glupa-C
- Appearance: yellow powder
- Storage conditions: room temperature
Constituent 1
Results and discussion
Small-scale preliminary testsopen allclose all
- Parameter:
- other: More sensitive to shock than m-dinitrobenzene
- Remarks:
- migrated information
- Remarks on result:
- not measured/tested
- Parameter:
- other: More sensitive to friction than m-dinitrobenzene
- Remarks:
- migrated information
- Remarks on result:
- not measured/tested
- Parameter:
- other: Explosive under influence of flame
- Remarks:
- migrated information
- Remarks on result:
- not measured/tested
- Parameter:
- other: Explosive (not specified)
- Remarks:
- migrated information
- Remarks on result:
- negative (not further specified)
Any other information on results incl. tables
PRELIMINARY TGA
From 325°C upwards the weight of the sample decreased significantly. At 363°C, the sample weight had decreased by 25%. After the experiment, a black molten residue remained in the sample container and the sample container was slightly expanded. The change of the colour indicated reaction and/or decomposition of the test substance.
DSC SCREENING TEST
With all experiments, a small endothermic peak between 150°C and 275°C was observed.
With the first and second experiment, an exothermic decomposition effect starting at 275°C was observed. The extrapolated onset temperature of the effectin the first experiment was 287.45°C. With the second experiment an onset temperature 282.57°C was obtained. The exothermic decomposition energy was 526.2 J/g in the first experiment and 475.1 J/g in the second test. Since the difference in exothermic decomposition energy between both experiment was > 10% a third experiment was performed.The extrapolated onset temperature of the effect in the third experiment was 284.30°C and the exothermic decomposition energy was 457.7 J/g. The CV calculated with the exothermic decomposition energies of all three determinations was 7.3%. Hence, results were accepted and the mean exothermic decomposition energy was obtained from Experiment 1, 2 and 3.
After the experiments, a black molten residue remained at the bottom of the sample container. The sample container was slightly expanded. It indicated reaction and/or decomposition of the test substance during the test.
Applicant's summary and conclusion
- Interpretation of results:
- non explosive
- Remarks:
- Migrated information
- Conclusions:
- From the results of a GLP-compliant study in accordance with UN Appendix 6 and EPA OPPTS 830.6316, the substance should be considered to present no danger of explosion. Exothermic decomposition of the substance of < 500 J/g (486 J/g was measured) was determined at a temperature of 285°C using DSC. The substance has no explosive properties.
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