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Diss Factsheets
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EC number: 217-703-5 | CAS number: 1934-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975-08-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for reliability but not in detail documented. Study report meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DOT (Transport-Classification) Guideliens
- Deviations:
- not specified
- Principles of method if other than guideline:
- The study was performed before GLP- and OECD-testing guidelines were available and in force. The intact and abraded skin of 6 albino rabbits was employed for this study.
- GLP compliance:
- no
- Remarks:
- GLP-guidelines not yet in force at date of the study
Test material
- Reference substance name:
- Sodium Dicyanamid
- IUPAC Name:
- Sodium Dicyanamid
- Test material form:
- other: solid
- Details on test material:
- Physical state: solid
The material to be tested (0.5 mg)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24 and 48 hours on intact and abraded skin
- Number of animals:
- 6 albino rabbits were employed for this study.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hour
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- no data
- Other effects:
- No data available.
Any other information on results incl. tables
Skin reaction |
Reading (hours) |
Individual scores – rabbit no. & sex |
|||||
1 |
2 |
3 |
4 |
5 |
6 |
||
Erytehma/Eschar |
4 24* 48* 72 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
Total of * 0 0 0 0 0 0 |
|||||||
Mean values of * 0.0 0.0 0.0 0.0 0.0 0.0 |
|||||||
Oedema |
4 24* 48* 72 |
0 0 0
|
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
Total of * |
|
0 |
0 |
0 |
0 |
0 |
0 |
Mean values of * |
|
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
Overall mean of * for Erythema/Eschar: 0.0
Overall mean of * for Oedema: 0.0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin.
- Executive summary:
The study was performed 1975, following the DOT (Transport Classification) Guidelines, before GLP- and OECD-testing guidelines were available and in force and amended in year 1991 (Addendum to Lonza Report No. 0155). A couple of substances were tested in one study. The intact and abraded skin of 6 albino rabbits was employed for this study. A series of 6 rabbits was used for testing each substance. The patches consisted of 1.5 inch x 1.5 inch 12 ply gauze squares. The patches were secured to the area by thin bands of adhesive tape (occlusive application). The material to be tested (0.5 mg) was introduced beneath the patch. The entire trunks of the animals were then wrapped in clear plastic trunk bands.
The irritation index is 0.0 and therefore, the test item will be not classified as skin irritant to the rabbit skin.
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