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EC number: 262-134-8 | CAS number: 60270-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 = 5.45 mg/L, analysed test concentrations of the untreated solution (OECD Guideline 203, semi-static; GLP, RL1)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.45 mg/L
Additional information
In a 96-h acute toxicity study according toOECD guideline 203 (Fish, Acute Toxicity Test) 1992 and EU Method C.1 (Acute Toxicity for Fish) 1992, juvenile rainbow trouts (Oncorhynchus mykiss) were exposed to DIMAPDO lactate at nominal concentrations of 1.0, 1.8, 3.2, 5.6 and 10 mg test substance/L (mean measured concentrations of untreated test medium: 0.63, 1.5, 2.9, 4.8 and 9.1 mg/L; mean measured concentrations of centrifuged test medium: 0.32, 0,76, 1.2, 2.6 and 6.6 mg/L) under semi-static conditions. The 96 -hour LC50 based on nominal test concentrations was 7.5 mg/L with 95% confidence limits of 5.6 - 10 mg/L. The 96 -hour LC50 based on mean measured concentrations of untreated test medium was 6.6 mg/L with 95% confidence limits of 4.8 - 9.1 mg/L.
The analysed test concentrations of the untreated solution (analysis of dispersed + dissolved test substance) and not of the centrifuged solution (analysis only of dissolved test substance) were chosen for further risk assessment because in the OECD guideline 201 study there was a discontinuity in the analysis of the concentrations of the centrifuged test solution and therefore the calculated values for the centrifuged test media were not valid. Additionally the examination of the dead fish revealed that the dispersed test material had adhered to the gill filaments indicating physical toxicity of the dispersed test material particles may be a factor in toxicity to fish.
Because the study was conducted with the lactic acid salt of DIMAPDO, the 96-h LC50 of DIMAPDO based on mortality and sublethal effects and the concentration analysis of the untreated test solution were calculated as 5.45 mg/L active ingredient.
Sub-lethal effects (moribundity) of exposure were observed at a nominal test concentration of 10 mg/L. Due to the approach of substantial severity limit these fish were killed and classed as mortalities at 24 and 48-hour time points respectively.
This toxicity study is classified as acceptable and satisfies the guideline requirement for a fish short-term toxicity study.
Results Synopsis
Test organism size/age: juvenile rainbow trouts (Oncorhynchus mykiss); mean length: 4.2 cm (SD = 0.1); weight: 0.90 g (SD = 0.21)
Test Type: semi-static (daily renewal)
LC50: 5.45 mg a.i./L 95% C.I.: 3.96 to 7.51 mg a.i./L
NOEC: 3.96 mg a.i./L
Endpoint(s) Effected: mortality
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