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EC number: 419-640-0 | CAS number: 68784-14-5 ALLYL SUCROSE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 April 2014 to 27 June 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD test guideline study performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenetics Tests: Erythrocyte Micronucleus Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Constitutional isomers of penta-O-allyl-β-D-fructofuranosylα-D-glucopyranoside; Constitutional isomers of hexa-O-allyl-β-D-fructofuranosylα-D-glucopyranoside; Constitutional isomers of hepta-O-allyl-β-D-fructofuransoylα-D-glucopyranoside
- EC Number:
- 419-640-0
- EC Name:
- Constitutional isomers of penta-O-allyl-β-D-fructofuranosylα-D-glucopyranoside; Constitutional isomers of hexa-O-allyl-β-D-fructofuranosylα-D-glucopyranoside; Constitutional isomers of hepta-O-allyl-β-D-fructofuransoylα-D-glucopyranoside
- Cas Number:
- 68784-14-5
- Molecular formula:
- C3H4O to C36H54O11
- IUPAC Name:
- 2-{[3,4-bis(prop-2-en-1-yloxy)-2,5-bis[(prop-2-en-1-yloxy)methyl]oxolan-2-yl]oxy}-3,4,5-tris(prop-2-en-1-yloxy)-6-[(prop-2-en-1-yloxy)methyl]oxane
- Test material form:
- other: straw coloured viscous liquid
- Details on test material:
- - Substance type: UVCB
- Physical state: straw coloured viscous liquid
- Analytical purity: not applicable
- Expiration date of the lot/batch: 04 April 2016
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK Ltd, Oxon, UK
- Age at study initiation: 6 to 10 weeks
- Weight at study initiation: 21 to 28g
- Assigned to test groups randomly: yes
- Fasting period before study: None
- Housing: solid-floor polypropylene cages
- Diet (e.g. ad libitum): ad libitum Harlan Teklad 2014C diet
- Water (e.g. ad libitum): ad libitum mains drinking water
- Acclimation period: five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 25C
- Humidity (%): 30 to 70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 23 April 2014 To: 27 June 2014
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- Arachis oil
- Details on exposure:
- Oral route by gavage.
- Duration of treatment / exposure:
- 24 and 48 hours
- Frequency of treatment:
- Single
- Post exposure period:
- 24 and 48 hours
- No. of animals per sex per dose:
- 7 males per group
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Cyclophosphamide 50 mg/kg
Examinations
- Tissues and cell types examined:
- Bone marrow polychromatic and normochromatic cells
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION:The maximum tolerated dose level was used as the highest dose (800 mg/kg). The two lower doses were 400 and 200 mg/kg.
TREATMENT AND SAMPLING TIMES ( in addition to information in specific fields): Dosed once at time 0 and sampled either 24 or 48 hours later.
DETAILS OF SLIDE PREPARATION: Femurs were aspirated with foetal bovine serum and bone marrow smears prepared folowing centrifugation and re-suspension. The smears were air-dried, fixed in absolute methanol, stained in May-Grunwald/Giemsa, allowed to air-dry and a cover slip applied using mounting medium.
METHOD OF ANALYSIS: Stained bone marrow smear were coded and examined blind using light microscopy at x1000 magnification. The incidence of micronucleated cells per 2000 polychromatic erythrocytes (PCE-blue staind immature cells) per animal was scored. Micronuclei ar enormally circular is shape, although occassionally they may be oval or half-moon shaped, and have a sharp contour with even staining. In addition, the number of normochromatic erythrocytes (NCE-pink stained mature cells) associated with 1000 erythrocytes was counted; these cells were also scored for the incidence of micronuclei. The ratio of polychromatic to normochromatic erythrocytes was calculated together with appropriate group mean values and standard deviation. - Evaluation criteria:
- A comparison was made between the number of MNPCE occuring in each of the test item groups and the number occuring in the vehicle control group. A positive mutagenic response was demonstrated when a statistically significant, dose-responsive, toxicologically relevant increase in the number of MNPCE was observed for either the 24 or 48 hour time points when compared to the vehicle control group. If these criteria were not fulfilled, then the test item was considered to be non-gentoxic under the conditions of the test. A positive response for bone marrow toxicity was demonstrated when the dose group mean PCE to NCE ratio was shown to be statistically significantl y lower than the vehicle control group.
- Statistics:
- The data were analyzed following a square root (x+1) transformation using Student's t-test (two tailed) and any significant results were confirmed using one-way analysis of variance.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- yes
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The test item was considered to be non-genotoxic under the conditions of the test. - Executive summary:
Introduction. The study wasa performed to assess the potential of the test item to induce damage to chromosomes or aneuploidy when adminstered to mice. The method was designed to be compatible with the 1997 OECD Guidelines for Testing of Chemicals No. 474 "Mammalian Eryuthrocyte Micronucleus Test".
Methods. A range-finding test was performed to find suitable dose levels of the test item, route of adminstration and to investigate if there was a marked difference in toxic response between the sexes. There was no marked difference in toxicity between the sexes and therefore the main test was performed in males only. The micronucleus test was conducted using the oral route in groups of seven male mice at the maximum tolerated dose of 800 mg/kg, with 400 and 200 mg/kg as the two lower dose levels. Animals were killed 24 or 48 hours later, the bone marrow extracted and smear preparation made and stained. Polychromatic (PCE) and normochromatic (NCE) erythrocytes were scored for the presence of micronuclei.
Results. There were no premature deaths seen in any of the dose groups. The following clinical signs were observed at 800 mg/kg in both the 24 and 48 -hour exposure groups: hunched posture and ptosis. No statistically significant decreases in the PCE/NCE ratio were observed in any test item dose group when compared to the vehicle control group. There was no evidence of any significant increases in the incidence on MNPCE in animals dosed with the test item when compared to the vehicle control group.The positive control group showed a marked increase in the incidence of MNPCE hence confirming the sensitivity of the system to the known mutagenic activity of cyclophosphamide under the conditions of the test.
Conclusion. The test item was considered to be non-genotoxic under the conditions of the test.
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