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EC number: 228-036-4 | CAS number: 6092-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The short-term toxicity of hexyl chloroformate to aquatic invertebrates was examined in a 48 -h screening study (BASF, 2007). From this study a 48 -h EC50 value of <10 mg/L was determined for daphnids (D. magna).
As the substance is expected to rapidly hydrolyse in contact with water to form hexanol (CAS 111 -27 -3), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9), key information on the hydrolysis products was gathered also.
For the hydrolysis product hexanol short-term toxicity data is available from published literature (Bringmann and Kühn, 1982). Although methodology is not decsribed in detail, the method appears to correspond to OECD 202. From the study a 24 -h EC50 of 201 mg/L is derived for daphnids (D. magna). Although this study has limited value for regulatory purposes, it gives indication of limited toxicity to aquatic invertebrates.
For the hydrolysis product hydrogen chloride a short-term study in aquatic invertebrates (D. magna) according to OECD guideline 202 is available (OECD SIDS, 2002). The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3).
For the hydrolysis product carbon dioxide no toxicity data are available for aquatic invertebrates.
In the screening study with the parent substance (2007), daphnids (D. magna) were exposed to 10 and 100 mg/L test substance straight after preparation of the test solutions and to 10 and 100 mg/L test substance after stirring for 24 hours. Immobility was recorded after 48 hours exposure. Both the 100 mg/L test solutions induced 100% immobility in daphnia. Exposure to 10 mg/L test substance straight after preparation of the test solution also induced 100% immobility whereas the 10 mg/L solution which was allowed to hydrolyse for 24 hours induced no immobility. Based on these findings the 48 -h EC50 value was determined at <10 mg/L. It may be concluded that toxicity is likely to be related to the high reactivity of unhydrolyzed hexyl chloroformate in the early phase of the test rather than to exposure to the hydrolysis product hexanol. The 24 -h EC50 value derived for hexanol further strengthens this conclusion.
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