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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-987-8 | CAS number: 112-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 117 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Overall assessment factor (AF):
- 6
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 705 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Correction factor of 1.763 for dose-response oral -> inhalation (according to R8 ECHA guidance)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 1
- Justification:
- An additional factor for "remaining interspecies differences" as proposed by ECHA is scientifically not justified and arbitrary since the allometric scaling factor fully accounts for interspecies differences [ECETOC. Technical Report in preparation: Guidance on Assessment Factors to Derive DNELs (2010), and Publication No. 901 of the Committee for Hazardous Substances (AGS) of the German Federal Institute for Occupational Safety and Health (BAuA) April 2010].
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC recommends in its Technical report No. 86 ("Derivation of Assessment Factors for Human Health Risk Assessment"; February 2003); and a default assessment factor for intraspecies differences of 3 for workers deviating from the ECHA proposed assessment factor of 5.
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
According to data of the structural analogue dioctyl ether the oral and dermal LD50 of dihexyl ether is > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure and a DNEL after short-time exposure must not to be derived.
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 666 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Overall assessment factor (AF):
- 24
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 40 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Based on the available data a skin penetration of max. 1% is assumed.
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 1
- Justification:
- An additional factor for "remaining interspecies differences" as proposed by ECHA is scientifically not justified and arbitrary since the allometric scaling factor fully accounts for interspecies differences [ECETOC. Technical Report in preparation: Guidance on Assessment Factors to Derive DNELs (2010), and Publication No. 901 of the Committee for Hazardous Substances (AGS) of the German Federal Institute for Occupational Safety and Health (BAuA) April 2010].
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC recommends in its Technical report No. 86 ("Derivation of Assessment Factors for Human Health Risk Assessment"; February 2003); and a default assessment factor for intraspecies differences of 3 for workers deviating from the ECHA proposed assessment factor of 5.
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
According to data of the structural analogue dioctyl ether the dermal LD50 of dihexyl ether is > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure and a DNEL after short-time exposure must not to be derived.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.554 mg/cm²
- Most sensitive endpoint:
- sensitisation (skin)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- other: EC3
- Value:
- 22.18
- AF for dose response relationship:
- 1
- Justification:
- not expected
- AF for differences in duration of exposure:
- 1
- Justification:
- no extension of exposure duration or exposure conditions (e. g. no occlusion) is expected
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not relevant for topical effects
- AF for other interspecies differences:
- 10
- Justification:
- Interspecies differences (according to ECHA Guidance R8 (Appendix R8-10))
- AF for intraspecies differences:
- 1
- Justification:
- not designated in ECHA Guidance R8 (Appendix R8-10)
- AF for the quality of the whole database:
- 1
- Justification:
- very good study report; data from another study in guinea pig also show that the substance is only moderately skin sensitising
- AF for remaining uncertainties:
- 1
- Justification:
- Vehicle effects: It is expected that the exposure with the substance will be in a matrix without penetration enhancer or irritants. No matrix effects are expected.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 34.8 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 378 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Correction factor of 0.87 for dose-response oral -> inhalation (according to R8 ECHA guidance)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 1
- Justification:
- An additional factor for "remaining interspecies differences" as proposed by ECHA is scientifically not justified and arbitrary since the allometric scaling factor fully accounts for interspecies differences [ECETOC. Technical Report in preparation: Guidance on Assessment Factors to Derive DNELs (2010), and Publication No. 901 of the Committee for Hazardous Substances (AGS) of the German Federal Institute for Occupational Safety and Health (BAuA) April 2010].
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC recommends in its Technical report No. 86 ("Derivation of Assessment Factors for Human Health Risk Assessment"; February 2003); and a default assessment factor for intraspecies differences of 5 for the general population deviating from the ECHA proposed assessment factor of 10.
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
According to data of the structural analogue dioctyl ether the oral and dermal LD50 of dihexyl ether is > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure and a DNEL after short-time exposure must not to be derived.
Local effects
Long term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 100 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Overall assessment factor (AF):
- 40
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 40 000 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Based on the available data a skin penetration of max. 1% is assumed.
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 1
- Justification:
- An additional factor for "remaining interspecies differences" as proposed by ECHA is scientifically not justified and arbitrary since the allometric scaling factor fully accounts for interspecies differences [ECETOC. Technical Report in preparation: Guidance on Assessment Factors to Derive DNELs (2010), and Publication No. 901 of the Committee for Hazardous Substances (AGS) of the German Federal Institute for Occupational Safety and Health (BAuA) April 2010].
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC recommends in its Technical report No. 86 ("Derivation of Assessment Factors for Human Health Risk Assessment"; February 2003); and a default assessment factor for intraspecies differences of 5 for the general population deviating from the ECHA proposed assessment factor of 10.
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
According to data of the structural analogue dioctyl ether the dermal LD50 of dihexyl ether is > 2000 mg/kg bodyweight. Therefore the substance is practically nontoxic after short-term exposure and a DNEL after short-time exposure must not to be derived.
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.554 mg/cm²
- Most sensitive endpoint:
- sensitisation (skin)
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- other: EC3
- Value:
- 22.18
- AF for dose response relationship:
- 1
- Justification:
- not expected
- AF for differences in duration of exposure:
- 1
- Justification:
- no extension of exposure duration or exposure conditions (e. g. no occlusion) is expected
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not relevant for local effects
- AF for other interspecies differences:
- 10
- Justification:
- Interspecies differences (according to ECHA Guidance R8 (Appendix R8-10))
- AF for intraspecies differences:
- 1
- Justification:
- not designated in ECHA Guidance R8 (Appendix R8-10)
- AF for the quality of the whole database:
- 1
- Justification:
- very good study report; data from a nother study in guinea pig also show that the substance is only moderately skin sensitising
- AF for remaining uncertainties:
- 1
- Justification:
- Vehicle effects: It is expected that the exposure with the substance will be in a matrix without penetration enhancer or irritants. No matrix effects are epected.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Longer exposure duration
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC recommends in its Technical report No. 86 ("Derivation of Assessment Factors for Human Health Risk Assessment"; February 2003); and a default assessment factor for intraspecies differences of 5 for the general population deviating from the ECHA proposed assessment factor of 10.
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.