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EC number: 252-525-1 | CAS number: 35355-77-2 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 15880:2.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984-08-08 - 1984-12-18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Manganese, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid complex
- EC Number:
- 252-525-1
- EC Name:
- Manganese, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-2-naphthalenecarboxylic acid complex
- Cas Number:
- 35355-77-2
- Molecular formula:
- C21H12MnN2O6S
- IUPAC Name:
- manganese(2+) hydrogen 3-oxido-4-[(E)-(1-sulfonatonaphthalen-2-yl)diazenyl]naphthalene-2-carboxylate
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- other: Til:RAI f SPE
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- ENVIRONMENTAL CONDITIONS
- Temperature: 21 +/- 1 °C
- Humidity: 65 % +/- 5 %
Administration / exposure
- Route of administration:
- oral: gavage
- Duration and frequency of treatment / exposure:
- single treatment
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 m³ of the formulation per animal corresponding to 33.17 mg/animal of the test substance
- No. of animals per sex per dose / concentration:
- 4 rats divided into two groups
- Control animals:
- yes
- Details on study design:
- rats received a single oral dose of 33.7 mg/animal of the test item and 10.0 mg/animal of β-naphthylamine. The residues of β-naphthylamine in urine of rats were measured after 24 hours and 48 hours.
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: 24h, 72h - Statistics:
- none
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- No residues of β-naphthylamine (<0.06 mg/dm3) were found in urine of rats within 48 hours after a single oral treatment with the test substance at a dose of 33.17 mg/animal. After a single oral treatment with β-naphthylamine at a dose of 10 mg/animal, residues of β-naphthylamine were found to range between 3.5 and 5.1 mg/dm3 in the 0-24 hours samples and to decrease to 0.14-0.24 mg/dm3 in the 24-48 hours samples.
Any other information on results incl. tables
Residues of β-naphthylamine in urine of rats after treatment with β-naphthylamine and with the test substance
Test substance |
Animal No. |
Animal weight g |
Application dosis mg/animal |
β-naphtylamine mg/dm3 |
|
0-24h |
24-48h |
||||
β-naphthylamine |
84185 plus 84186 |
201.4 199.2 |
10.0 10.0 |
3.5 |
0.14 |
84187 plus 84188 |
210.4 201.2 |
10.0 10.0 |
5.1 |
0.24 |
|
Test substance |
84177 plus 84178 |
205.7 199.4 |
33.17 33.17 |
<0.06 |
<0.06 |
84179 plus 84180 |
198.4 203.8 |
33.17 33.17 |
<0.06 |
<0.06 |
|
Control |
84189 plus 84190 |
197.3 208.4 |
- - |
<0.06 |
<0.06 |
84191 |
194.4 |
- |
<0.06 |
<0.06 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.