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EC number: 253-452-8 | CAS number: 37294-49-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 18, 2013 - July 17, 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with OECD guideline 121. Non-GLP study. The substance is surface active and, according to the guideline, this method may not work for such a substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- (2001)
- GLP compliance:
- not specified
- Remarks:
- no information
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- Disodium C-isodecyl sulphonatosuccinate
- EC Number:
- 253-452-8
- EC Name:
- Disodium C-isodecyl sulphonatosuccinate
- Cas Number:
- 37294-49-8
- Molecular formula:
- C14H26O7S.2Na
- IUPAC Name:
- disodium 4-[(2-methylnonyl)oxy]-4-oxo-3-sulfonatobutanoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of test material (as cited in study report): Disodium Isodecyl Sulfosuccinate
Description: white powder
Storage conditions of test material: at room temperature in well-sealed container
The substance was tested as received.
Constituent 1
- Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- HPLC CONDITIONS
Instrument: Agilent 1200 with Chemstation Data system
Column: HALO ES-CN 2.7 µm (4.6 mm x 50 mm)
Column temperature: 30°C
Mobile phase: 55/45 (v/v) methanol/water (Milli-Q)
Flow: 0.8 mL/min
Injection volume: 5 µL
UV detection: 210 nm
SOLUTIONS
Test substance: 1 g/L of test substance in water
Unretained component: 3 g/L of formamide in water
Reference substances: 0.1 g/L solutions in 50/50 (v/v) methanol/water of benzamide, N,N-dimethylbenzamide, Phenol, 4-Nitrobenzamide, aniline, naphthalene, linuron, phenyl benzoate and fenthion.
PERFORMANCE OF THE STUDY
The unretained component, reference substance and test substance solutions were injected into the HPLC system. The capacity factor (k') of each substance was calculated from its retention time and the dead time (i.e. 0.682 minutes). The log k’ values of the references substances were plotted against the log Koc value provided by the OECD 121 guideline (based on soil adsorption data).
The equation of the calibration curve was calculated to be: log k’ = 0.663 x log Koc – 1.5573 (r^2=0.9388).
Using this equation, the log k' of the test substance was used to calculate the log Koc of the test substance.
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Value:
- 1.59
- Remarks on result:
- other: See the remark below on the temperature.
- Type:
- Koc
- Value:
- 36.3
Results: HPLC method
- Details on results (HPLC method):
- Calibration curve and HPLC chromatogram of the test substance solution are included in the attachment. The large peak at 0.896 minutes was assumed to be from the main constituent of the test substance.
Remark:
The test was performed at 30°C (i.e. the temperature of the column), but the log Koc value(s) obtained can be considered to represent the value(s) at an unspecified, probably ambient temperature (ca. 20°C) since no mention is made in the guidelines of the temperature at which the reference substance’s log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Any other information on results incl. tables
Table: Koc determination results
|
Retention time [min] |
Capacity factor k' |
log k’ |
log Koc |
Formamide |
0.682 |
|
|
|
Test substance |
0.896 |
0.314 |
-0.503 |
1.59 |
Reference compounds |
||||
Benzamide1 |
0.799 |
0.172 |
-0.766 |
1.26 |
N,N-Dimethylbenzamide2 |
0.859 |
0.260 |
-0.586 |
1.52 |
Phenol2 |
0.91 |
0.334 |
-0.476 |
1.32 |
4-Nitrobenzamide1 |
0.913 |
0.339 |
-0.470 |
1.93 |
Aniline2 |
1.046 |
0.534 |
-0.273 |
2.07 |
Naphthalene2 |
1.855 |
1.720 |
0.236 |
2.75 |
Linuron2 |
2.176 |
2.191 |
0.341 |
2.59 |
Phenyl benzoate1 |
2.235 |
2.277 |
0.357 |
2.87 |
Fenthion2 |
3.583 |
4.254 |
0.629 |
3.31 |
1 From OECD TG 121 , Annex Table 1
2 From OECD TG 121, Annex Table 3
Applicant's summary and conclusion
- Conclusions:
- Using the HPLC method as described in OECD guideline 121 and using soil-adsorption-reference data, the log Koc for the test substance was determined to be 1.59.
- Executive summary:
The HPLC method as described in OECD guideline 121, using 55/45 (v/v) methanol water as mobile phase and using soil-adsorption-reference data, was applied for the determination of the adsorption coefficient (Koc) of the test substance. The column temperature was 30°C. The dead time was determined by using formamide. The main constituent of the substance showed a large peak in the HPLC-UV chromatogram. From its retention time the log Koc of the substance was calculated to be 1.59 (Koc: 36.3). The result has to be treated with care as the surface active property of the substance might influence the outcome of this HPLC method.
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