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EC number: 270-099-5 | CAS number: 68411-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION OF TEST SOLUTION
- Separetely for each concentration 0.50 g, 1.00 g, 50.00 g and 100.00 g test substance were added to 10 l test water and the mixture was homogenized using an ultra-turrax stirrer.
- Dispersed undissolved test substance was visible in all concentrations at the water surface increasing with the concentratinos and in the 50 and 100 mg/L group decreasing with time due to sedimentation.
- After about 24 h undissolved test substance was visible in all concentrations on the bottom increasing with the concentratinos.
- All test solutions were colored blue increasing with the concentrations. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- GENERAL INFORMATION
- Animal supplier: Bio International B.V., AP Roermond, NL
- Age of animals: about 7 months
- Body length: 2.81 (2.1 - 3.1) cm
- Body weight: 0.22 (0.14 - 0.28) g
HOUSING
- Fish were kept in a flow-through tank in tap water, not chlorinated, passed through a charcoal filter and aerated with oil-free air
- Duration of housing: about 2 months
- Photoperiod: 16 h light : 8 h dark
- Water temperature: 21 - 22 °C
- Mortality: during the last 7 days: 0 %
- Diet: "TETRA MIN" standard feed for aquarium fish, TETRA-WERKE, Melle, FRG, ad libitum; and on workdays generally additionally live brine shrimp - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 22 - 23 °C
- pH:
- 8.2 - 8.5
- Dissolved oxygen:
- 7.5 - 9.0 mg/L
- Nominal and measured concentrations:
- - Concentrations tested (nominal): 50, 100, 5000 and 10000 mg/L plus control
- Details on test conditions:
- TEST WATER
- Municipal water of the city of Frankenthal, not chlorinated and passed through a charcoal filter, aerated
- Test water properties:
Total hardness: about 2.5 mmol/L
Acid capacity: about 5.5 mmol/L
Ca content: about 90 mg/L
Mg content: about 10 mg/L
pH: about 8.0 - 8.6
TEST SYSTEM
- Test vessels: all-glass aquaria (30 x 22 x 24 cm)
- Test volume: 10 L (water depth about 17 cm)
- No. animals / vessel: 10
- Loading (g fish / l water): approx. 0.2 g/L
FURTHER TESTING CONDITIONS
- Photoperiod: 16 h light : 8 h darkness
- Withdrawl of food: 1 day before and during exposure
- Aeration: slight - Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- no analytical monitoring, a solubiliser was used
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Lot/batch No.: 7051
- Name of test material (as cited in study report): Hostaperm Blue BG - Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 4 g test substance were mixed with 4 g Tween 80 and filled up with test water to 40 l
- Controls: 4 g Tween 80 mixed with 40 l reconstituted water
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Tween 80 - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Common carp
- Source: Fisheries Research Station, University of Agricultural Sciences, Bangalore, India
- Length at study initiation (length definition, mean, range and SD): 3.1 - 4.0
ACCLIMATION
- Acclimation period: 48 h
- Type and amount of food: commercial fish feed
- Feeding frequency: once daily
- Health during acclimation (any mortality observed): no mortality observed - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 22 +/- 2 °C
- pH:
- 7.88 +/-0.14
- Dissolved oxygen:
- 82 +/- 8 %
- Nominal and measured concentrations:
- Nominal test concentrations:
control,
solvent control,
100 mg/l - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria (40 l)
- Type (delete if not applicable): open / closed
- Fill volume: 20 l
- Renewal rate of test solution (frequency/flow rate): every 24 h
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: max. 1 g fish/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and symptoms after 1, 2, 4, 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 0, 100 mg/l
- Results used to determine the conditions for the definitive study: LC50 >100 mg/l - Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No observation of symptoms of intoxication possible since test water was densely coloured by the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to attached justification.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Referenceopen allclose all
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
There are no studies available that assess the acute toxicity of the test substance to fish. However, as the test substance belongs to the substance group of Phthalocyanines whose group members resemble in their chemical structure as well as in their phys-chem properties, a read-across approach was used to cover this endpoint.
A study on the toxicity of CAS 59160-79-1 to fish revealed no toxicity to fish (LC50 > 10000 mg/L) at test determination after 96h. This test was run in a static system according to OECD 203 with analytical monitoring [BASF 1999].
One further study is available for the source substance CAS 147-14-8 which was performed similar to OECD 203 using the common carp (Cyprinus carpio) as test species, too. The test concentrations were prepared using a vehicle. The 96-h LC50 was given as > 100 mg/L. Analytical monitoring was not performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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