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EC number: 203-766-6 | CAS number: 110-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (48 h) = 1700 mg/L (nominal)
LC50 (48 h) > 100 mg/L < 300 mg/L (nominal)
LC50 (48 h) = 170 mg/L (nominal)
LC50 (96 h) > 0.52 mg/L (measured)
Key value for chemical safety assessment
Additional information
A study evaluating the acute toxicity of methyl decanoate (CAS No. 110-42-9) to fish is available, lasting for 48 hours. According to the Guidance on information requirements and chemical safety assessment, chapter R.7b, results obtained at shorter test durations that the standard 96 hours (OECD 203) should be treated with caution and always in combination with other data (read-across, non-testing, etc.). Therefore, according to Regulation (EC) No. 1907/2006, Annex XI, 1.2, a Weight of Evidence (WoE) approach is applied to cover adequately this endpoint, using the available data from methyl decanoate in conjunction with the acute fish tests from structurally related category members in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5.
The test for methyl decanoate (CAS No. 110-42-9) was conducted according to DIN Guideline 38412/15 (German national standard method) with a test period of 48 hours (Richterich and Mühlberg, 2001). Fish (Leuciscus idus) were exposed to the test substance within a static water regime, at nominal concentration ranging from 10 to 10,000 mg/L. After the exposure period, mortality was observed only at the two highest concentrations tested (3000 and 10000 mg/L) whereas no effects were observed at any other concentration. This values lead to a LC50 (48 h) of 1700 mg/L.
There are two additional reports available by the same authors (Richterich and Mühlberg, 2001) for methyl hexanoate (CAS No. 106-70-7) and methyl octanoate (CAS No. 111-11-5). Both were conducted according to the German national DIN Guideline 38412/15 as well for 48 hours. Leuciscus idus was used as test organism and the same static procedure as for methyl decanoate was applied, with concentrations ranging from 10 to 10000 mg/L (nominal). After exposure to methyl hexanoate, 100% mortality was reported at nominal concentrations of 300 mg/L and above, leading to a LC50 (48 h) of 170 mg/L (nominal). In the case of methyl octanoate (CAS No. 111-11-5), 100% mortality was observed at concentrations of 300 mg/L and above, with effects observed as well at a concentration of 100 mg/L (40% mortality). The LC50 (48 h) for this substance was determined to be > 100 mg/L and <300 mg/L. Additionally, a study conducted with methyl laurate (CAS No. 111-82-0) according to OECD Guideline 203 (Fish, Acute toxicity) and according to the Japanese Circular on Test Methods of New Chemical Substances under GLP conditions, is available (Japanese Ministry of Environment, 2006).Oryzias latipeswas exposed to the test substance within a flow-through water regime for 120 hours, at a concentration of 1 mg/L (nominal). No mortality or other adverse effects were observed at the concentration tested, leading to a LC50 (96 h) > 0.52 mg/L (measured value).
Even considering the limitations of the 48-hours studies, effect concentrations for fish lower than those observed in the aquatic invertebrates and algae tests would be highly unlikely after a 96-hours exposure to methyl decanoate. Since results from 96 hours-studies in the category show that fish species are not the most sensitive aquatic organisms when exposed to this type of substances, the combined results from the acute fish studies for methyl decanoate (CAS No. 110-42-9), methyl hexanoate (CAS No. 106-70-7), methyl octanoate (CAS No. 111-11-5) and methyl laurate (CAS No. 111-82-0) are considered adequate to cover this endpoint.
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