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EC number: 213-063-6 | CAS number: 921-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-03-04 to 2003-05-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,3-trichloroacetone
- EC Number:
- 213-063-6
- EC Name:
- 1,1,3-trichloroacetone
- Cas Number:
- 921-03-9
- Molecular formula:
- C3H3Cl3O
- IUPAC Name:
- 1,1,3-trichloropropan-2-one
- Details on test material:
- - Name of test material (as cited in study report): 1,1,3-Trichloraceton
- Substance type: Industrial chemical
- Physical state: liquid
- Purity test date: not given in report
- Lot/batch No.: 1TC112013
- Expiration date of the lot/batch: 2002-12-31
- Stability under test conditions: stable
- Storage condition of test material: room temperature in the dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
OTHER PROPERTIES (if relevant for this endpoint)
- Results of test for ready biodegradability: not readily biodegradable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: all
- Sampling method: One aliquod from the freshly prepared test meda of all concentrations was taken at the start of the test before filling the test vessels. One combined aliquod was collected from the test media of all 4 exposure vessels of all test concentrations at the end of the study to determine the stability.
-Storage of the samples: at -20 °C
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTIONS
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: LPT Löhndorf, Germany
- Age at study initiation (mean and range, SD):
- Weight at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD):
- Valve height at study initiation, for shell deposition study (mean and range, SD):
- Peripheral shell growth removed prior to test initiation:
- Method of breeding:
- Feeding during test
- Food type:
- Amount:
- Frequency:
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food:
- Feeding frequency:
- Health during acclimation (any mortality observed):
QUARANTINE (wild caught)
- Duration:
- Health/mortality:
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- h
- Post exposure observation period:
- not stated in report
Test conditions
- Hardness:
- 250 mg CaCO3
- Test temperature:
- 20 +/- 1 °C
- pH:
- 7.9 +/- 0.3
- Dissolved oxygen:
- > 80% of maximum saturation
- Salinity:
- freshwater
- Nominal and measured concentrations:
- 0.01, 0.0215, 0.0464, 0.1, 0.215, 10 and 100 mg/l (nominal = measured)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 190 x 90 mm, 2 l
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Ca/mg ratio: 4:1
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light 8 hours dark
- Light intensity: 500 lux +/- 20 %
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : EC50 - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not applicable
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.215 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not applicable
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.215 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not applicable
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not applicable
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.021 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: not applicable
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.12 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 0.08 - 0.24 mg/l
- Details on results:
- - Behavioural abnormalities: not observed
- Observations on body length and weight: not give in report
- Mortality of control: 0
- Other adverse effects control: none
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- not available
- Reported statistics and error estimates:
- The EC50 (48 h) was calculated by linear regression analysis employing probit analysis. The EC50 (24 h), NOEC values were taken directly from the raw data.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 1,1,3 -Trichloroacetone is very toxic for the aquatic invertebrate Daphnia magna under the con-ditions used in this test
- Executive summary:
Young Daphnia were exposed in a static immobilisiation test according to OECD guideline 202 in order to evaluate the influence of 1,1,3 -Trichloroacetone on the mobility and survival. Daphnia magna were exposed in a static test for 48 hours to the test medium which contained the test substance up to 100 mg/l in test water.
The test medium of the highest concentration of 100 mg/l exposure medium was prepared by mixing 100 mg test item into 1 l test water by intense stirring for approx. 30 minutes. The solution obtained was user as stock solution for lower concentrated test media.
The nominal concentrations tested were 0.01, 0.0215, 0.0464, 0.100, 0.215 10 and 100 mg/l. Aditionally a control was tested in parallel. Aliquots were taken at the beginning and end of the exposure period for GC-analysis. The GC-analysis revealed correctly prepared exposure media. The analytical results obtained were within +/- 20 % of the nominal concentrations. The reported biological results are related to nominal concentrations.
The NOEC was 0.0100mg/l (24 h and 48 h), the EC50 was 0.215 mg/l (24 h) and 0.12 mg/l (48 h with a 95% confidence interval of 0.08-0.024 mg/l). It could be stated that 1,1,3 -Trichloroacetone is very toxic for the aquatic invertebrate Daphnia magna under the conditions used in this test.
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