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EC number: 284-660-7 | CAS number: 84961-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Benzene, mono-C10-13-alkyl derivs., distn. residues
- EC Number:
- 284-660-7
- EC Name:
- Benzene, mono-C10-13-alkyl derivs., distn. residues
- Cas Number:
- 84961-70-6
- Molecular formula:
- Not available - not a single isomer, see remarks below
- IUPAC Name:
- Benzene, mono-C10-13-alkyl derivs., distn. residues
- Reference substance name:
- Benzene, mono-C10-13-alkyl derivs., distillation residues
- IUPAC Name:
- Benzene, mono-C10-13-alkyl derivs., distillation residues
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomae GmbH, Biberach
- Age at study initiation: adult
- Weight at study initiation: 2-3 kg
- Housing: individually in stainless steel cages, identified by ear tags
- Diet (e.g. ad libitum): Ssniff K 4, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 degree C
- Humidity (%): 30-70%
- Air changes (per hr): 15 air changes/hr
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
IN-LIFE DATES: From: Oct. 19, 1992 To: Oct. 26, 1992
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye was used as control.
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
24 hrs- Observation period (in vivo):
- Readings were taken at 1, 24, 48, and 72 hours, and 6 days after the application.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- A single application to the conjunctival sac of the right eyelid. The substance was not washed out.
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: fluorescein stain
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 0.55
- Reversibility:
- fully reversible within: 6 days
- Irritant / corrosive response data:
- All three animals exhibited conjunctival erythema (score of 1) at the 1 hr reading and through the 24 hr reading. By the 48 hr reading, these symptoms had resolved in all but one animal. This animal continued to show conjunctival erythema through the 72 hr reading, but by the day 6 reading, its symptoms had resolved as well.
Any other information on results incl. tables
Results of Eye Irritation Study
Animal |
1 hr |
24 hr |
48 hr |
72 hr |
6 days |
|
1 |
Conjunctiva - Erythema |
1 |
1 |
1 |
1 |
0 |
Conjunctiva ¿ Chemosis |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
2 |
Conjunctiva - Erythema |
1 |
1 |
0 |
0 |
0 |
Conjunctiva ¿ Chemosis |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
3 |
Conjunctiva - Erythema |
1 |
1 |
0 |
0 |
0 |
Conjunctiva ¿ Chemosis |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
|
Cornea |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance is not classified as an eye irritant according to EU GHS guidelines.
- Executive summary:
This study examined the potential of the test substance to cause irritation to eyes. 0.1 ml of test substance was placed in one eye of three male rabbits. The untreated eye served as control. The animals were examined for signs of irritation at 1, 24, 48, and 72 hours after application. All three animals showed signs of conjunctival erythema (score of 1) at the 1 hr observation. By the 48 hr observation, these symptoms had resolved in all but one animal. This animal continued to show irritation at the 72 hr observation. For this reason, the study was extended to determine the reversibility of the symptoms. At the next observation at day 6, symptoms had resolved in all animals. The mean irritation score was 0.55. The test substance is not classified as an eye irritant under EU GHS guidelines.
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