Registration Dossier
Registration Dossier
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EC number: 203-313-2 | CAS number: 105-60-2
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- About the pharmacologic and toxic activities of E-Caprolactam.
- Author:
- Hohensee F.
- Year:
- 1 951
- Bibliographic source:
- Faserforschung und Textiltechnik 8, 299-303
- Reference Type:
- publication
- Title:
- About the pharmacologic and toxic activities of E-Caprolactam.
- Author:
- Hohensee, F.
- Year:
- 1 951
- Bibliographic source:
- Fiber Res. and Textile Tech. 1, 299-303. Cited in: Henschler, D. (Hrsg.), Gesundheitsschaedliche Arbeitsstoffe. Toxikologisch-arbeitsmedizinische Begruendung von MAK-Werten: Caprolactam (1975), 1.-17. Lfg., Verlag Chemie (1991)
Materials and methods
- Principles of method if other than guideline:
- Eight mice each were injected subcutaneous daily with test substance at the rate of 50 and 150 mg/kg bw for 42 days. Three animals were kept as control.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- ε-caprolactam
- EC Number:
- 203-313-2
- EC Name:
- ε-caprolactam
- Cas Number:
- 105-60-2
- Molecular formula:
- C6H11NO
- IUPAC Name:
- azepan-2-one
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): epsilon-Caprolactam
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 42 days
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 50 mg/kg bw/day
- Dose / conc.:
- 150 mg/kg bw/day
- No. of animals per sex per dose:
- 8
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No abnormalities were detected
Applicant's summary and conclusion
- Conclusions:
- No abnormalities were detected.
- Executive summary:
Eight mice each were injected subcutaneous daily with test substance at the rate of 50 and 150 mg/kg bw for 42 days. Three animals were kept as control.
No abnormalities were detected
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