Registration Dossier
Registration Dossier
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EC number: 203-614-9 | CAS number: 108-77-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No individual data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC 84/449/EEC
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4,6-trichloro-1,3,5-triazine
- EC Number:
- 203-614-9
- EC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Cas Number:
- 108-77-0
- Molecular formula:
- C3Cl3N3
- IUPAC Name:
- 2,4,6-trichloro-1,3,5-triazine
- Details on test material:
- Cyanuric chloride, purity > 99%.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- weight 2.5-3.0 kg
age 4-12 weeks
Test system
- Amount / concentration applied:
- Application of 0.1 g test substance into the conjunctival sac.
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- Observations at 1, 24, 48 and 72 h and 7 and 30 days
- Number of animals or in vitro replicates:
- 4 (sex not indicated)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 23
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 58
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 66
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 70
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 78
- Irritation parameter:
- other: Index of ocular lesions (according to Draize)
- Basis:
- mean
- Time point:
- other: 30 days
- Reversibility:
- fully reversible within: 30 days
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- Irritating.
- Executive summary:
The primary irritancy of Cyanuric chloride was tested after single application to the eye of the rabbit. 4 animals were included in this study. Tha application dosage was 0.1 g of the test substance into the conjunctival sac. Observations were made at 1, 24, 48 and 72 h and 7 and 30 days. According to the index of ocular lesions (Draize), Cyanuric chloride is irritating.
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