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Diss Factsheets
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EC number: 203-471-2 | CAS number: 107-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 402.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity and Skin corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
- Author:
- Vernot EH, MacEwen JD, Haun CC & Kinkead ER
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42, 417 - 423
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC & Striegel, JA
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 23, 95 - 107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- , 3 animals are used (Study was performed prior to OECD GL 402)
- GLP compliance:
- no
- Remarks:
- test predated GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Prop-2-yn-1-ol
- EC Number:
- 203-471-2
- EC Name:
- Prop-2-yn-1-ol
- Cas Number:
- 107-19-7
- Molecular formula:
- C3H4O
- IUPAC Name:
- prop-2-yn-1-ol
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Initial body weight of rabbits: 3-4 kg, Diet: ad libidum, Purina Rabbit Chow.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervoius plastic film. Dosages greater than 20 ml/kg cannot be retained in contact with the skin. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14-day observation period (Smyth et al., 1962).
- Duration of exposure:
- 24 hr
- Doses:
- Not indicated
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
The method used for skin absorption toxicity was essentially that of Smyth et al. (1962), except that three female albino New Zealand rabbits (3 - 4 kg) were used per dose and the doses were kept in place by 8-ply gauze patches under a latex rubber film (method: 24-hour occlusive application). The rabbits were maintained on Purina Rabbit Chow.
Smyth HF, Carpenter CP, Weil CS, Pozzani UC & Striegel, JA (1962). Range-Finding Toxicity Data: List VI, Am. Ind. Hyg. Assoc. J. 23, 95 - 107
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 88 mg/kg bw
- Mortality:
- Mortality is only given as LD50
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Executive summary:
In an acute dermal toxicity study one group of New Zealand rabbits (3 females) was dermally exposed to Propargyl alcohol for 24 hours. Animals then were observed for one day. The dermal LD50 was estimated as 88 mg/kg bw.
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