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Diss Factsheets
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EC number: 201-607-5 | CAS number: 85-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Temperature in the vapor inhalation chamber raised to 60 - 70 degree Celsius, no individual animal data, no analytic of test atmosphere, limited documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Zur Toxizitaet von reinem Phthalsaeureanhydrid und Rohprodukten aus der industriellen Phthalsaeuresynthese (Tierexperimentelle Untersuchungen)
- Author:
- Friebel H, Gross E, Immisch-Seehausen L, Linke KH, Sommer S
- Year:
- 1 956
- Bibliographic source:
- Arch. Gewerbepath. Gewerbehyg. 14, 465-482.
Materials and methods
- Principles of method if other than guideline:
- 4 guinea pigs (2 animals on 4 consecutive days, 2 animals on 8 consecutive days) were exposed to the vapour of the test substance (3 different qualities) for 30 min. The impact of the vapour on the animals was studied.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phthalic anhydride
- EC Number:
- 201-607-5
- EC Name:
- Phthalic anhydride
- Cas Number:
- 85-44-9
- Molecular formula:
- C8H4O3
- IUPAC Name:
- 1,3-dihydro-2-benzofuran-1,3-dione
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Remarks on MMAD:
- MMAD / GSD: not applicable - vapour
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 2 animals on 4 consecutive days, 2 animals on 8 consecutive days
- Frequency of treatment:
- single
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 different qualities in different doses were used: see - any other information on materials and methods
Basis:
- No. of animals per sex per dose:
- Total (m+f): 2 animals on 4 consecutive days, 2 animals on 8 consecutive days
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
All animals including the control animals showed irritation of
conjunctiva, and irritation of lung mucosa probably because the
temperature in the vapor inhalation chamber increased to 60 - 70 degree
Celsius during the experiment.
Controls:
Respiration-rate (decrease of respiration rate, breathing/min)
C 78,5
P 60,6
K7 53,7
K2 41,2
closed eyelids, transient rhinitis.
Histopathology: no findings in the lung.
P:
abdominal respiration.
Histopathology: only 1 animal showed bronchitis, impaired mucous
membranes and increased number of histiocytes.
K2:
increased lacrimation, complete eyelid closure, rhinitis, laboured
breathing.
Histopathology: animals showed putrid bronchitis, hyperemia of the lungs.
K7:
signs of irritation, closed eyelids, lacrimation, slight rhinitis,
Cuogh-rate (per 30 min)
C 8
P 201
K7 1117
K2 343
Histopathology: slight bronchitis was seen.
Applicant's summary and conclusion
- Executive summary:
4 guinea pigs ( 2 animals on 4 consecutive days, 2 animals on 8 consecutive days) were exposed to the vapour of the the test substance (3 different qualities) for 30 min. the impact of the vapour on the animals was studied.
Result: no NO(A)EL or LO(A)EL stated; all animals showed decreaswed respiration rate, closed eyelids and transient rhinitis. the histopathological examination revealed no findings in the lung.
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