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Diss Factsheets
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EC number: 200-817-4 | CAS number: 74-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- A mortality study of employees at a synthetic rubber manufacturing plant.
- Author:
- Holmes, T. M. et al.
- Year:
- 1 986
- Bibliographic source:
- Am J Ind Med. 1986;9(4):355-62, as cited in: OECD SIDS Chloromethane, 2004
Materials and methods
- Study type:
- cross sectional study
- Endpoint addressed:
- carcinogenicity
- Principles of method if other than guideline:
- A mortality follow-up study was conducted of workers employed at a synthetic rubber manufacturing plant in Baton Rouge, Louisiana. Interest in the potential health effects of exposure to methyl chloride, one of the substances used in the manufacturing process, provided the impetus for this study.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
- Details on test material:
- - Name of test material (as cited in study report): methyl chloride
- Analytical purity: no data
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- The study cohort consisted of 852 male process workers who had worked at least 1 month during the period from startup of operations in 1943 through December 31, 1978.
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Mortality from all causes was lower than expected when compared with the U.S. male population. No excess mortality from any specific cause of death was found in the study population after analysis by level and duration of exposure.
There was no increase in deaths due to cancer in this study population, but the study has only limited statistical power.
External causes of death were too few to calculate significance.
In general, less than expected mortality occurred in every category and no cause of death was in statistical excess. - Strengths and weaknesses:
- The authors noted the small size and low power of their study.
Any other information on results incl. tables
TABLE 1
Observed and Expected* Deaths From Selected Causes Among White Male Butyl Rubber Workers First Employed In Butyl Rubber Operations During the Period 1943-1950 by Potential for Exposure to Methyl Chloride
Cause of Death (ICD-8th rev) |
Low |
Medium |
High |
|||
Obs/Exp |
SMR** |
Obs/Exp |
SMR |
Obs/Exp |
SMR |
|
All causes (001-998) |
7 / 12.6 |
56 |
16 / 22.1 |
72 |
69 / 77.5 |
89 |
Malignant neoplasms (140-209) |
1 / 2.4 |
42 |
2 / 4.4 |
45 |
10 / 15.5 |
65 |
Circulatory system diseases (390-458) |
3 / 6.3 |
48 |
10 / 11.0 |
91 |
43 / 40.0 |
108 |
External causes of death (800-998) |
2 / 1.5 |
133 |
3 / 2.3 |
30 |
7 / 7.0 |
100 |
* Expected numbers are based on calendar time and age-specific mortality rates of white males.
**(Observed/expected) x 100. (Holmes, et al., 1986).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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