Registration Dossier
Registration Dossier
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EC number: 215-185-5 | CAS number: 1310-73-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Data sharing dispute
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 3 reliability score was assigned since documentation is insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- No title available
- Author:
- Naunyn-Schmiedeberg's
- Year:
- 1 937
- Bibliographic source:
- Archiv für experimentielle Pathologie und Pharmakologie (Berlin, Germany), 184, 587-604
Materials and methods
- Principles of method if other than guideline:
- other (not specified)
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Sodium hydroxide
- EC Number:
- 215-185-5
- EC Name:
- Sodium hydroxide
- Cas Number:
- 1310-73-2
- Molecular formula:
- HNaO
- IUPAC Name:
- sodium hydroxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 2500-3500 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 160-940 mg/kg bw
MAXIMUM DOSE VOLUME APPLIED: 4.9-31 ml/kg body weight - No. of animals per sex per dose:
- 46 animals (no data for sex)
- Control animals:
- not specified
- Statistics:
- not described
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 325 mg/kg bw
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
