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EC number: 265-196-4 | CAS number: 64742-93-4 A complex black solid obtained by blowing air through a heated residuum, or raffinate from a deasphalting process with or without a catalyst. The process is principally one of oxidative condensation which increases the molecular weight.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is assigned a Klimisch score of 2. Although the study report does not provide sufficent data, the results of this study can be utilized. Not a GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Pre-guideline study according to the Draize methodology
- GLP compliance:
- no
Test material
- Reference substance name:
- Asphalt, oxidized
- EC Number:
- 265-196-4
- EC Name:
- Asphalt, oxidized
- Cas Number:
- 64742-93-4
- Molecular formula:
- Not applicable
- IUPAC Name:
- Asphalt, oxidized
- Reference substance name:
- Asphalt Sample 77220
- IUPAC Name:
- Asphalt Sample 77220
- Test material form:
- liquid: viscous
- Details on test material:
- Described as sample 77220.
The material is steep compounding (airblown).
CAS number 64742-93-4
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
Amount applied: 0.5 other: g - Duration of treatment / exposure:
- 24hrs
- Number of animals or in vitro replicates:
- 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 1.5
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Study authors concluded that irritation was due to the physical nature of the test material
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: included within conjunctivae score
Any other information on results incl. tables
The only effect noted was conjunctival reddening (score 2)at the 1 hour observation period in 3 of 4 rabbits.
No other effects were observed.
It is assumed that the irritation that occurred was due to the physical nature of the test material.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 24 -, 48 -, and 72 -hour mean scores for cornea, iris, and conjunctival irritation were observed to be 0. Based on these results, the test material is not considered to be an ocular irritant.
- Executive summary:
In an ocular irritation test in albino rabbits, 0.5 g of the test material (asphalt sample 77220) was applied to the conjunctival sac of 4 animals. Observations for eye irritation were made at 1, 24, 48 hours and 7 days after treatment.
For the one hour observation the test material was removed from the conjunctival sac and after evaluation a fresh sample of 0.5 g wasre-introduced into the conjunctival sac.
The test material was removed from the conjunctival sac 24 hours after the first treatment.The only effect noted was conjunctival reddening (score 2) at the 1 hour observation period in 3 of 4 rabbits. 24 -, 48 -, and 72 -hour mean scores
for cornea, iris, and conjunctival irritation were observed to be 0.
Based on these results, the test material is not considered to be an ocular irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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