Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-494-3 | CAS number: 85536-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-05-1 to 2003-05-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study well documented, followed guideline, with analytical.
- Justification for type of information:
- Category Approach; test material is reference substance LAS. LAS provides suitable read across for LAB Sulfonic Acids as both form the identical chemical species in aqueous solutions at neutral (physiological) pH, namely, the LAS ion (C10-13linear alkyl benzene-SO3-) and would be expected to have similar eco-toxicological properties.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- This study was not conducted under GLP but is a guideline study, of high scientific quality with considerable documentation.
Test material
- Reference substance name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- EC Number:
- 270-115-0
- EC Name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- Cas Number:
- 68411-30-3
- Molecular formula:
- Not applicable for UVCB
- IUPAC Name:
- sodium 4-undecylbenzenesulfonate
- Details on test material:
- - Name of test material: LAS Pantera (SS1147.01)
- Molecular weight: LAS Pantera: 318.12
- Substance type: Pure active substance
- Physical state: Liquid
- Stability under test conditions: Not available
- Storage condition of test material: At room temperature
- Color: Brown
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Samples were taken from all test concentrations at 0 and 72h (fresh solutions), and at 24 and 96h (24 h old solutions).
- Sampling method: Samples were collected and immediately preserved with 30% (v/v) methanol and an internal standard of deuterated C12-LAS was added to facilitate quantitation.
- Sample storage conditions before analysis: Not available
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Stock solutions of LAS material were prepared in high quality water at 1 g/L. Stock solutions were neutralized to a pH of 8.6 using NaOH. Test solutions were prepared by dilution of the stock solution in the dilution water (a blend of well and reverse osmosis water).
- Controls: A blend of well water and Reverse Osmosis Water.
- Evidence of undissolved material: No
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead Minnow
- Strain: Not available
- Source: Breeders obtained from Aquatic Research Organisms (ARO, Hampton, NH, USA). Test organisms were reared from eggs from the in-house breeding culture.
- Age at study initiation: Not specified.
- Length at study initiation: Average length: 2.74 cm, SD-0.264cm, Range-2.30-3.22 cm
- Weight at study initiation: Average weight: 0.189 g, SD-0.0615g, Range-0.101-0.317 g
- Method of breeding: In-house breeding; continuous batch culture; 20 L culture vessels; blended water (mix of well and RO water) was culture water; Temp 20.6-21.4°C; DO 7.7-8.9; pH 7.26-8.21; Food - live brine shrimp, flake food; 16:8 hr light:dark.
- Feeding during test: No
ACCLIMATION
- Acclimation period: Test organisms were bred/maintained under the same conditions as the test. The length of the 'acclimation' period was therefore the same as the age of the test organisms.
- Acclimation conditions: Same as test
- Type and amount of food: Live brine shrimp, flake food
- Feeding frequency: Twice daily
- Health during acclimation (any mortality observed): No mortality in the week prior to testing
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Not available. But the blend of well and RO water has a hardness of ~180 mg/L as CaCO3.
- Test temperature:
- LAS-Pantera: range 20.6-21.4 Degree C
- pH:
- LAS-Pantera: range 7.26-8.27. Details on pH measurements are provided in a Table below.
- Dissolved oxygen:
- LAS-Pantera: range 7.3-8.5 mg/L. Details on DO measurements are provided in a Table below.
- Nominal and measured concentrations:
- Nominal concentrations for LAS-Pantera: 0, 0.25, 0.5, 1, 2, 4, 8, 16 mg/L were based on the active ingredient in the test material.
Measured concentrations for LAS-Pantera: 0, 0.24, 0.57, 0.98, 2.1, 3.96, 7.61, 13.9 mg/L were based on the active ingredient.
Measured concentrations were 87-114% of nominal. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material: 19 L Glass aquaria, 10 L of solution
- Aeration: Not available
- Renewal rate of test solution: Daily renewal (24,48,72 h)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2 replicates
- No. of vessels per control (replicates): 2 replicates
- Biomass loading rate: 0.19 g/L.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: South west well water and reverse Osmosis water blended together
- Total organic carbon: Not available
- Particulate matter: Not Available
- Metals: Not Available
- Pesticides: Not Available
- Chlorine: Not Available
- Alkalinity: Not Available
- Ca/mg ratio: Not Available
- Conductivity: 370-425 umhos/cm for LAS-Pantera
- Culture medium different from test medium: No
- Intervals of water quality measurement: Temperature, DO, pH and conductivity measured daily in control and each test concentration.
OTHER TEST CONDITIONS
- Adjustment of pH: Not applicable
- Photoperiod: 16 h light :8 h dark
- Light intensity: 7-10uE/m2.s
EFFECT PARAMETERS MEASURED: Mortality was observed at 24, 48, 72 and 96 h .
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.0
- Range finding study: No, but the test concentrations were based on SAR predictions. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 2.10-3.96 mg/L
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 2.10-3.96 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 2.10-3.96 mg/L
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 2.10-3.96 mg/L
- Details on results:
- - Behavioural abnormalities: None
- Observations on body length and weight: No significant change in body weight and length
- Other biological observations: None
- Mortality of control: None
- Other adverse effects control: None
- Abnormal responses: None
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: No
- Effect concentrations exceeding solubility of substance in test medium: No - Reported statistics and error estimates:
- Mortality results were summarized and 96 hr LC50 estimates and 95% confidence limits were generated using the Binomial Probability Method.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1: % Mortality in Acute Toxicity Test (study #45725; LAS Pantera) (20 fish/test concentration)
Time (hr)
Active Ingredient of Test Substance (measured concentration; mg/L)
0
0.24
0.57
0.98
2.1
3.96
7.61
13.9
24
0
0
0
0
0
100
100
100
48
0
0
0
0
0
100
100
100
72
0
0
0
0
0
100
100
100
96
0
0
0
0
0
100
100
100
Table 2: Acute Toxicity of 7 LAS Substances to Fathead Minnow (Study # 45725)
Test Material 96 hr LC50 (mg/L) 95% CL (in mg/L) C10 LAS 16.6 15.0 – 18.3 C11 LAS 7.08 6.76 – 7.42 C12 LAS 1.63 1.49 – 1.78 C13 LAS 0.63 0.55 – 0.71 C14 LAS 0.26 0.23 – 0.30 LAS Veneco (C10,12,14) 2.22 2.02 – 4.35 LAS Pantera (C10,11,12,13) 2.88 2.10 – 3.96 Results are based on measured test concentrations.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- (Criteria of OECD 203: Mortality of controls <10%, conc. of dissolved oxygen >60%, exposure concentrations based on measured concentrations)
- Conclusions:
- The 96 hr LC50 of LAS Pantera to Fathead minnows was 2.88 mg a.i./L, based on measured concentrations of active ingredient.
- Executive summary:
In a 96 h static renewal acute toxicity study, Fathead minnow (Pimephales promelas) were exposed to LAS Pantera at nominal concentrations of 0 (control), 0.25, 0.5, 1, 2, 4, 8, and 16 mg a.i./L. Measured concentrations were 0 (control), 0.24, 0.57, 0.98, 2.1, 3.96, 7.61, and 13.9 mg a.i./L. Measured concentrations were 87 -114% of nominal.
The 96 h LC50 value, based on measured test concentrations, for LAS- Pantera was 2.88 mg a.i./L with 95% confidence interval of 2.10 to 3.96 mg a.i./L.
This toxicity study is classified as acceptable and satisfies the guidelines requirement for the OECD 203 fish acute toxicity study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.