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Diss Factsheets
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EC number: 231-197-3 | CAS number: 7446-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1950
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older published study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Sulfuric Acid Mist
- Author:
- Treon JF, Dutra FR, Cappel J, Sigmon H, & Younker W
- Year:
- 1 950
- Bibliographic source:
- American Medical Association (Reprinted from the Archives of Industrial Hygiene and Occupational Medicine, Vol. 2, December 1950, pages 716-734),
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of acute inhalation toxicity in different species, with different concentrations and durations of exposure
- GLP compliance:
- no
- Remarks:
- older published study
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
- Details on test material:
- Sulphuric acid mists, 10-60%
Constituent 1
Test animals
- Species:
- other: Rat, rabbit, guinea pig, mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: water
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- >= 2.75 - <= 7 h
- Concentrations:
- 0.09 or 1.73 mg/l
- No. of animals per sex per dose:
- Various
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 0.087 mg/L air
- Exp. duration:
- 2.75 h
- Remarks on result:
- other: Guinea pig
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.461 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Rat
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 0.699 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Rat
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.718 mg/L air
- Exp. duration:
- 3.5 h
- Remarks on result:
- other: Rat
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 1.47 mg/L air
- Exp. duration:
- 3.5 h
- Remarks on result:
- other: Rat
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.461 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Mouse
- Sex:
- not specified
- Dose descriptor:
- other: LC40
- Effect level:
- 0.699 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Mouse
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.699 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Rabbit
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 1.61 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Rabbit
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.718 mg/L air
- Exp. duration:
- 3.5 h
- Remarks on result:
- other: Rabbit, LC50 = 1.470 mg/l
Any other information on results incl. tables
Guinea-pigs, mice, rats, and rabbits were found to be less susceptible in that order. Observed lesions from the exposures included degenerative changes of the epithelium of the respiratory tract, pulmonary hyperemia and edema, focal pulmonary hemorrhages in some instances, and areas of atelectasis and emphysema in the lungs of all animals.
Applicant's summary and conclusion
- Conclusions:
- Guinea-pigs, mice, rats, and rabbits were found to be less susceptible in that order.
- Executive summary:
Mortality data, length of survival, signs of intoxication, and pathological changes are reported for animals exposed to 0.090 or 1.73 milligrams per liter of air of sulfuric-acid mists in a test chamber. Guinea-pigs, mice, rats, and rabbits are found to be less susceptible in that order. Observed lesions from the exposures included degenerative changes of the epithelium of the respiratory tract, pulmonary hyperemia and edema, focal pulmonary hemorrhages in some instances, and areas of atelectasis and emphysema in the lungs of all animals.
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