Registration Dossier
Registration Dossier
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EC number: 202-849-4 | CAS number: 100-41-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Animal data on skin sensitisation tests with ethylbenzene are not available. There are no reports of skin sensitisation caused by this substance at the workplace, nor does it contain any structural or other alerts to suggest it may induce or elicit an allergic state. A human patch test with 10% ethylbenzene in petrolatum revealed no skin sensitisation potential (Kligman, 1974) , cited in Opdyke, 1975). Taking into account the long time of human experience with this substance, it can be assumed that skin sensitisation is not a hazard that has to be expected when handling ethylbenzene. This assessment is in line with the fact that also for benzene as parent compound of alkylated benzenes there are no reports on sensitisation caused at the workplace. Thus, no sensitisation potential is expected for ethylbenzene.
Migrated from Short description of key information:
Based on the results of a human study ethylbenzene is not sensitising to the skin. No structural or other alerts are present to suggest it may induce or elicit an allergic state.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Animal data on inhalation sensitisation tests with ethylbenzene are not available. There are no reports of inhalation allergy caused by this substance at the workplace, nor does ethylbenzene contain any structural or other alerts to suggest it may induce or elicit an allergic state. Results from animal repeated dose toxicity studies provide no evidence of respiratory signs or microscopic changes in lung tissue suggestive of a potential to cause respiratory sensitization. Taking into account the long time of human experience with this substance, it can be assumed that respiratory allergy is not a hazard that has to be expected when handling ethylbenzene. This assessment is in line with the fact that also for benzene as parent compound of alkylated benzenes there are no reports on sensitisation caused at the workplace. Thus, no sensitisation potential is expected for ethylbenzene.
Migrated from Short description of key information:
No studies of respiratory sensitisation have been conducted, but there are no human reports of respiratory sensitisation. Animal repeated dose inhalation studies provide no evidence of respiratory signs or microscopic changes suggestive of respiratory sensitization.
Justification for classification or non-classification
Animal data on skin or inhalation sensitization tests with ethylbenzene are not available, however it contains no structural or other alerts to suggest it may induce or elicit an allergic state. There are no reports on skin sensitisation or inhalation allergy caused by this substance at the workplace. A human patch test with 10% ethylbenzene in petrolatum revealed no skin sensitization potential. Taking into account the long time of human experience with this substance, it can be assumed that skin sensitisation or respiratory allergy is not a hazard that has to be expected when handling ethylbenzene. This assessment is in line with the fact that also for benzene as parent compound of alkylated benzenes there are no reports on sensitization caused at the workplace. Results from animal repeated dose toxicity studies provide no evidence of respiratory signs or microscopic changes in lung tissue suggestive of a potential to cause respiratory sensitization. Thus, no sensitization potential is expected for ethylbenzene and classification according to Directive 67/548/EEC,EU CLP (Regulation (EC) No. 1272/2008) and UN GHS is not warranted.
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