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EC number: 200-751-6 | CAS number: 71-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fate of n-Butanol in rats after oral administration and its uptake by dogs after inhalation or skin application
- Author:
- DiVincenzo GD, Hamilton ML
- Year:
- 1 979
- Bibliographic source:
- Toxicology and applied Pharmacology 48: 317-325
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dogs were exposed to n-[1-14C]Butanol dermally for 60 minutes. Breath and urine was collected for 8 hours. The dermal absorption and also the excretion of butanol was determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): n-[1-14C]butanol
- Specific activity (if radiolabelling): 1.71 mCi/mmol
- Locations of the label (if radiolabelling): n-[1-14C]butanol - Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Marshall Research Animals, Inc. Noth Rose, NY, USA
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: unspecified carrier
- Duration of exposure:
- 60 min
- Doses:
- 20 µCi n-[1-14C]butanol in carrier
- No. of animals per group:
- 2 males
- Control animals:
- no
- Details on study design:
- APPLICATION OF DOSE: 20 µCi n-[1-14C]butanol in 15 mL carrier
TEST SITE
- Preparation of test site: hair was clipped 24 h before application
- Area of exposure: ca. 55.6 cm2 on thorax
- Type of cover / wrap used: A sealed glass absorption cell which was secured with surgical adhesive and tape was used. Cotton gauze was placed inside the cell to facilitate the uniform distribution of solvent over the surface of the skin.
SITE PROTECTION / USE OF RESTRAINERS FOR PREVENTING INGESTION: Yes, animals were anesthetized with sodium pentobarbital. Atropine sulfate was given as preanesthetic.
SAMPLE COLLECTION
- Collection of urine: continuously by an urethral catheter
- Collection of expired air: continuously in a Saran bag by means of an oral endotracheal tube connected to a two-way valve. The contents of the Saran bag were passed through a silica gel trap to adsorb unchanged n-[14C]butanol and through a sodium hydroxide trap to collect 14CO2.
Radioactivity excreted in the breath and urine from a skin exposure was compared to the excretion of radioactivity by dogs dosed intravenously with 1 mg/kg n-[1-14C]butanol.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- The elimination of radioactivity after the application of n-[1-14C]butanol to the skin of two male beagle dogs was examined. After 60 min, 29 mg of n-butanol was absorbed through the skin of each dog. The absorption rate was 8.8 µg/min/cm2. The excretion of radioactivity was ca. 15 dpm in breath and ca. 3 dpm in urine.
Skin absorption calculations were based on the 8-hr excretion of radioactivity in the breath and urine of dogs dosed intravenously with n-[1-14C]butanol (1 mg/kg bw). For those animals the elimination is expressed as a percentage of the administered dose. About 15 % of the dose was eliminated in the breath as 14CO2 and 2.7 % was excreted in the urine. There was no unchanged n-butanol detected in the breath. The 8-hr elimination of radioactivity in the breath and urine averaged about 17 % of the administered dose.
The assumption was made that the metabolic fate and disposition of n-[14C]butanol is identical after iv or skin administrations.
Percutaneous absorptionopen allclose all
- Key result
- Time point:
- 60 min
- Parameter:
- amount
- Absorption:
- 29 other: mg
- Key result
- Time point:
- 60 min
- Parameter:
- rate
- Absorption:
- 8.8 other: µg/min/cm2
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.