Registration Dossier
Registration Dossier
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EC number: 203-845-5 | CAS number: 111-20-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- in chemico
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- 1. SOFTWARE
EPI Suite v. 4.11
2. MODEL (incl. version number)
DERMWIN v. 2.02
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
OC(=O)CCCCCCCCC(O)=O
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6
- Version / remarks:
- May/July 2008
- GLP compliance:
- no
Test material
- Reference substance name:
- Sebacic acid
- EC Number:
- 203-845-5
- EC Name:
- Sebacic acid
- Cas Number:
- 111-20-6
- Molecular formula:
- C10H18O4
- IUPAC Name:
- sebacic acid
Constituent 1
Results and discussion
Percutaneous absorption
- Absorption:
- 0.001 cm/h
- Remarks on result:
- not measured/tested
- Remarks:
- only in silico calculation available
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption is regarded as low with an estimated Kp value of 0.00114 cm/hr.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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