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Diss Factsheets
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EC number: 202-705-0 | CAS number: 98-83-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older study: meets scientific standards with acceptable restrictions (limited number of animals in study, partly limited documentation).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: Study from 1972 (no guidelines available at the time the study was performed)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- 0.1 mL of undiluted sample was placed in the conjunctival sac of the right eye of each of 3 albino male and female rabbits and observations made over a period of 7 days for inflammation. The eyes were rinsed after 24 hrs and the left eye served as control.
Scoring according to Draize et al. (1944) J Pharm Exp Therap 82 - GLP compliance:
- no
- Remarks:
- Study from 1972 (GLP was not compulsory at the time the study was performed)
Test material
- Reference substance name:
- 2-phenylpropene
- EC Number:
- 202-705-0
- EC Name:
- 2-phenylpropene
- Cas Number:
- 98-83-9
- Molecular formula:
- C9H10
- IUPAC Name:
- (prop-1-en-2-yl)benzene
- Details on test material:
- Lot/batch No.: 68 T 1
crude test substance (no further data)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 24 hrs
- Observation period (in vivo):
- 168 hrs
- Number of animals or in vitro replicates:
- 3 male and female NZW rabbits
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 14
- Max. score:
- 110
- Reversibility:
- fully reversible within: 120 hrs
Any other information on results incl. tables
Numerical evaluations at the end of ... hrs |
||||||
Animal / Sex |
1 |
24 |
48 |
72 |
120 |
168 |
1 - female |
14 |
10 |
4 |
2 |
0 |
0 |
2 - female |
14 |
8 |
4 |
2 |
0 |
0 |
3 - female |
14 |
8 |
4 |
2 |
0 |
0 |
Average |
14 |
8.6 |
4 |
2 |
0 |
0 |
Observations following application:
Immediate |
Severe discomfort, with pawing, squealing, and trashing about the stocks |
10 min |
severe erythema, slight oedema, copious discharge |
1 hr |
moderate erythema, slight oedema, copious discharge |
24 hrs |
moderate erythema, very slight oedema, slight discharge |
48 hrs |
slight erythema and discharge |
72 hrs |
slight erythema |
120 hrs |
eyes normal; zero readings |
168 hrs |
eyes normal; zero readings |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- The substance was slighty irritating.
- Executive summary:
In this older study 0.1 mL of undiluted sample was placed in the conjunctival sac of the right eye of each of 3 albino male and female rabbits and observations made over a period of 7 days for inflammation. The eyes were rinsed after 24 hrs and the left eye served as control. Scoring according to Draize et al. (1944) J Pharm Exp Therap 82.
With an average maximum score of 14 in one hour (possible: 110) the TS was classed as slightly irritating in male and female rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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