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Diss Factsheets
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EC number: 310-193-6 | CAS number: 1345-16-0 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77346
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-09-08 to 1987-09-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- the purity of the test material was missing in the study report Minor deviations from the guideline: - in this study only males were given the test item. According to the guideline, after completion of the study in one sex one group of the other sex is dosed to establish that animals of this sex are not markedly more sensitive to the test substance. Where adequate information is available to demonstrate that the animals of the sex tested are markedly more sensitive, testing in animals of the other sex may be dispensed with. If males are more sensitive to the test item than females was not stated in the report, but since the LD50 for males lies above 10000 mg/kg it is assumed that the LD50 for the females is also above 2000 mg/kg and no testing of females is needed. - the acclimatisation period in this study was four days - the administered test volume was not stated - information on temperature and relative humidity (holding conditions) were missing. - time of appearance and disappearance of clinical signs was not stated. In addition, number of animals displaying signs of toxicity was not shown. - bodyweight should be determined at the day of administration and then weekly thereafter and at death. The body weight was determined at the day of administration and at the end of the study (Day 14). - the age of the rats was missing in the study report. Since the weight of the rats was between 200 and 300 g, it was assumed that the rats were young adults.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987-02-24
- Deviations:
- yes
- Remarks:
- , please refer to "Rationale for reliability incl. deficiencies" above
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cobalt aluminate blue spinel
- EC Number:
- 310-193-6
- EC Name:
- Cobalt aluminate blue spinel
- Cas Number:
- 1345-16-0
- Molecular formula:
- Co(x)Al(3-x)O4 1≤x≤1,5
- IUPAC Name:
- Cobalt aluminium spinel
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Blue 214 - Cobalt Aluminate
- Physical state: royal blue coloured powder
- Storage condition of test material: stored at room temperature throughout the study in a large plastic clear jar with a black taped black lid.
No further information on the test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 222 to 255 grams
- Fasting period before study: overnight prior to dosing food was denied.
- Housing: the rats were housed in groups of five in stainless steel wire mesh suspension cages.
- Diet (ad libitum, except during the fasting period prior to dosing): animals were maintained on PURINA LABORATORY CHOW
- Water (ad libitum): tap water
- Acclimation period: at least four days prior to dosing
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- DOSAGE PREPARATION: the test material was administered as a 50 % w/v formulation in distilled water.
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for gross signs of systemic toxicity and mortality several times during the day of dosing and once daily thereafter for 14 days.
- Necropsy of survivors performed: yes; at the end of the observation period, the rats were weighed, killed by carbon dioxide inhalation and given a gross necropsy. - Statistics:
- not applicable
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the obervation period.
- Clinical signs:
- other: Clinical changes observed during the observation period are as follows: 1. Mild depression 2. Faecal stains 3. Blue sample-like stains on coats 4. Blue mucoid faeces on cage paper 5. Blue-sample-like stains on fur
- Body weight:
- other body weight observations
- Remarks:
- All animals gained bodyweight (mean bodyweight gain: 59 g (S.D. = 11 g).
- Gross pathology:
- Gross necropsies performed at the end of the study revealed no gross pathological changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (male rats) > 10000 mg/kg
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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