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EC number: 215-684-8 | CAS number: 1344-00-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Principles of method if other than guideline:
- Beckman Coulter LS Particle Size Analyzer
- GLP compliance:
- not specified
- Type of method:
- electrical sensing zone (e.g. Coulter) method
- Specific details on test material used for the study:
- ZEOCOPY 133 ex HAM
- Mass median aerodynamic diameter:
- 5.19 µm
- Key result
- Percentile:
- D50
- Mean:
- 5.19 µm
- Remarks on result:
- other: no standard deviation measured
- No.:
- #6
- Size:
- 26.45 µm
- Distribution:
- < 99 %
- No.:
- #5
- Size:
- 17.29 µm
- Distribution:
- < 95 %
- No.:
- #4
- Size:
- 13.33 µm
- Distribution:
- < 90 %
- No.:
- #3
- Size:
- 5.19 µm
- Distribution:
- < 50 %
- No.:
- #2
- Size:
- 1.887 µm
- Distribution:
- < 10 %
- No.:
- #1
- Size:
- 1.383 µm
- Distribution:
- < 5 %
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Principles of method if other than guideline:
- Beckman Coulter LS Particle Size Analyzer
- GLP compliance:
- not specified
- Type of method:
- electrical sensing zone (e.g. Coulter) method
- Specific details on test material used for the study:
- ZEOLEX 23D ex ETW
- Mass median aerodynamic diameter:
- 8.797 µm
- Key result
- Percentile:
- D50
- Mean:
- 8.797 µm
- Remarks on result:
- other: no standard deviation measured
- No.:
- #6
- Size:
- 39.02 µm
- Distribution:
- < 99 %
- No.:
- #5
- Size:
- 25.73 µm
- Distribution:
- < 95 %
- No.:
- #4
- Size:
- 20.71 µm
- Distribution:
- < 90 %
- No.:
- #3
- Size:
- 8.797 µm
- Distribution:
- < 50 %
- No.:
- #2
- Size:
- 3.038 µm
- Distribution:
- < 10 %
- No.:
- #1
- Size:
- 2.229 µm
- Distribution:
- < 5 %
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- Laser scattering/diffraction
- Specific details on test material used for the study:
- Name: SODASIL®P-95
Batch no.: 937201AS
Appearance: fine, white powder
Composition: Silicic acid, aluminium sodium salt >98 %
CAS No.: 1344-00-9
EINECS-No.: not stated
Molecular formula: nSiO2.mAl2O3.zNa2O
Molecular weight: not stated
Purity: >98 % Silicic acid, aluminium sodium salt
Homogeneity: homogeneous
Vapour pressure: not stated
Production date: 10. Sep. 2019
Expiry date: 10. Sep. 2021
Storage: room temperature (20 ± 5 °C) - Key result
- Percentile:
- D50
- Mean:
- 449.18 µm
- St. dev.:
- 11.23
- No.:
- #1
- Size:
- 74 µm
- Distribution:
- 0.06 %
- No.:
- #2
- Size:
- 250 nm
- Distribution:
- 11.62 %
- No.:
- #3
- Size:
- 420 µm
- Distribution:
- 44.52 %
- No.:
- #4
- Size:
- 500 µm
- Distribution:
- 61.47 %
- No.:
- #5
- Size:
- 600 µm
- Distribution:
- 79.92 %
- No.:
- #6
- Size:
- 1 020 µm
- Distribution:
- 100 %
- Conclusions:
- The test substance SODASIL P-95 has a median particle size D50 = 449.18 ± 11.23 μm at the dispersion method GRADIS/L, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981) and ISO 13320 (2009).
- Executive summary:
The main objective of this study was the determination of the dustiness based on a laser diffraction analyses of the test substance. Also a particle size distribution was performed. The results on the later are documented here, those in chapter 4.28.8 in more detail.
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of method:
- Laser scattering/diffraction
- Specific details on test material used for the study:
- Name: ZEOCOPY 133
Batch no.: 258100211
CAS No.: 1344-00-9
Stability: H2O: ; EtOH: ; acetone: ; CH3CN: ; DMSO: Solubility: H2O: not stated; EtOH: not stated; acetone: not stated; CH3CN: not stated; DMSO: not stated;
Storage: room temperature (20 ± 5 °C) - Key result
- Percentile:
- D50
- Mean:
- 345.1 µm
- St. dev.:
- 2.15
- Conclusions:
- The test substance ZEOCOPY 133 has a median particle size D50 = 345.10 ± 2.15 μm at the dispersion method GRADIS/L, which was determined by laser diffraction measurement according to OECD Test Guideline 110 (1981) and ISO 13320 (2009).
- Executive summary:
The objective of this study was the determination of the dustiness based on a laser diffraction analyses of the test substance, but also its PSD was determined. Only the latter is documented here, the results on dustiness can be found in chapter 4.28.8.
Referenceopen allclose all
Calculations from 0.040 μm to 2000 μm
Volume: 100%
Mean: 6.661 μm
Median: 5.190 μm
Mean/Median ratio: 1.284
Mode: 5.355 μm
Calculations from 0.040 μm to 2000 μm
Volume: 100%
Mean: 10.72 μm
Median: 8.797 μm
Mean/Median ratio: 1.219
Mode: 10.29 μm
For the test substance SODASILP-95 and the selected aerodynamic cut-off diameter of 100 μm following values of the inhalable fraction, the thoracic fraction and the alveolar fraction were calculated and given:
Mean value + SD (mg/kg): Inhalable 21531 +/- 1782; Thoracic 4 +/- 1; Alveolar 0 +/- 0
For the test substance SODASIL®P-95 and the selected aerodynamic cut-off diameter of 37 μm following values of the inhalable fraction, the thoracic fraction and the alveolar fraction were calculated and given:
Mean value + SD (mg/kg): Inhalable 436 +/- 87; Thoracic 2 +/- 0; Alveolar 0 +/- 0
Description of key information
Silicic acid, aluminum sodium salt's typical median particle size ranges from 5.1 to 8.8 μm, measured under high shear forces as a result of wet dispersion. Under low shear forces as a result of dry dispersion, the particle size was measured up to 449 μm.
Additional information
Particle Size: Definition and Dynamic Interactions:
With respect to particle size, the German standard DIN 53206 (1972) distinguishes between primary particles, aggregates and agglomerates.
Primary particles in the case of synthetic amorphous Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) do not exist in isolation.
Aggregates are assemblies of primary particles which are grown together face-to-face in the form of chains or clusters. The aggregates are formed by the collision of primary particles during particle growth and/or by the further deposition of particles onto these aggregates. Agglomerates are assemblies of aggregates, held together by strong physical adhesion forces.
Shear forces cause a breakdown of agglomerates, as well as dissolution tends to prevent the formation of larger agglomerates due to the larger interparticle distances and low collision frequencies. Under the technical conditions of inhalation exposure of experimental animals, in general, high shear forces dominate that form aerosols of small particle sizes with a high fraction of respirable particles. This is in marked contrast to the largely stressless settling conditions that prevail under normal handling and use of these materials.
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