Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-906-6 | CAS number: 7778-50-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: NTP study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: NTP
- Principles of method if other than guideline:
- NTP combined repeated dose / reproductive toxicity screening study.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Potassium dichromate
- EC Number:
- 231-906-6
- EC Name:
- Potassium dichromate
- Cas Number:
- 7778-50-9
- Molecular formula:
- K2Cr2O7
- IUPAC Name:
- sodium dichromate
- Details on test material:
- No further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- Animals were exposed for up to 9 weeks
- Frequency of treatment:
- Continous
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0, 15, 50, 100, 400 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
0, 1, 3, 6. 24 (M); 0, 1, 3, 7, 28 (F) mg/kg bw/d
Basis:
actual ingested
- Remarks:
- Doses / Concentrations:
0, 0.4, 1, 2, 8 (M); 0, 0.4, 1, 2, 10 (F) mg/kg bw/d
Basis:
other: Cr (VI) equivalents
- No. of animals per sex per dose:
- 24 males; 48 females
- Control animals:
- yes, plain diet
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 400 ppm
- Sex:
- male/female
- Basis for effect level:
- other: No effects of toxicological significance were seen at the highest dose level in this study.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No deaths or treatment-related clinical signs of toxicity were observed. No effects were seen on body weight, water and food consumption, organ weights and microscopic evaluation of the liver, kidneys and ovaries. During haematological investigations, a statistically significant decrease of 3% and 6% in mean corpuscular volume (MCV) was seen at week 3 in the 400 ppm females and at week 9 in the 400 ppm males, respectively. Although not statistically significant, the MCV values were also decreased by 3% in the 400 ppm females at week 9. This effect returned to normal in all animals after the recovery period. The mean corpuscular haemoglobin (MCH) was also significantly decreased at week 9 in the 400 ppm males (by 5%) and in the 400 ppm females (by 6%). After the recovery period, the MCH was again comparable across groups. Decreases in the MCV and MCH are also considered to be of no toxicological significance since the decreases were small, were stated to be within historical control ranges, and since both the MCV and MCH are derived indices using the haematocrit, erythrocyte count, or haemoglobin concentration and no treatment-related differences were observed in these latter parameters. No alterations in structure or relative cell numbers were found in the testes.
Applicant's summary and conclusion
- Conclusions:
- Dietary administration of potassium dichromate for 9 weeks to rats did not produce any significant toxicity up to the highest dose level tested of 24 mg/kg/day (8 mg Cr(VI)/kg/day) and 28 mg/kg/day (10 mg Cr(VI)/kg/day) in males and females, respectively.
- Executive summary:
Groups of 24 male and 48 female Sprague-Dawley rats were administered in the diet 0, 15, 50, 100 or 400 ppm of potassium dichromate , corresponding to mean dose levels of approximately 0, 1, 3, 6 and 24 mg/kg/day (0, 0.4, 1, 2 and 8 mg Cr(VI)/kg/day) in males, and 0, 1, 3, 7, and 28 mg/kg/day (0, 0.4, 1, 2 and 10 mg Cr(VI)/kg/day) in females, respectively, for 9 weeks. Six males and 12 females from each dose group were then terminated after 3, 6 or 9 full weeks of treatment and after a recovery period of 8 weeks. Investigations of body weight, food and water consumption, organ weights, microscopic evaluation of the liver, kidney and ovaries, haematology, histology of the testis and epididymis for Sertoli nuclei and preleptotene spermatocyte counts in stage X or XI tubules, and chromatin analysis were included. Treatment-related findings were limited to minor effects on haematological parameters in 400 ppm females; findings are not considered to be of toxicological significance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.