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EC number: 215-105-9 | CAS number: 1302-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-04-23 - 2009-11-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Type of study / information:
- Determination of the resorption in the digestive tract of Spinel according to DIN 19738.
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 19738
- Deviations:
- yes
- Remarks:
- The composition of the test item was not determined, but calculated from information provided by the sponsor. Temperature in some conducts was outside the range of 37 ± 1 °C.
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 19738
- Deviations:
- yes
- Remarks:
- The sediment was not leached with deionised H2O after centrifugation in order to avoid further dilution. The samples were stored in closed vessels at 2 - 8°C. The solutions were centrifuged at 2000 g, instead at 7000 g.
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- yes
- Remarks:
- The test item is a powder and was used without preparation (not ground).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Spinel (Mg(AlO2)2)
- EC Number:
- 215-105-9
- EC Name:
- Spinel (Mg(AlO2)2)
- Cas Number:
- 1302-67-6
- Molecular formula:
- AlO2.1/2Mg
- IUPAC Name:
- magnesium dialuminium oxide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Findings and Results:
Two tests with and two tests without the addition of full milk powder have been performed, as well as two blanks with and without milk powder.
An aliquot of the remaining solutions then was thermically digested and resoluted in conc. HCl and water. The resulting solutions were measured via AAS for Mg and Al.
Al determinations were below LOQ, only Mg showed values a little above the blanks in samples which were digested with the addition of milk powder.
The mobilised masses of the measured elements and the bioaccessibilities are given in tabular form.
Samples without addition of milk powder:
Sample Mg 1 2 Mean sd RSD
mobilised masses of test item in µg/g 82.5 427 254 244 96%
bioaccessibility in % 4.9*10-4 2.5 *10-3 1.5 *10-3 1.4 *10-3 96%
Samples with addition of milk powder:
Sample Mg 3 4 Mean sd RSD
mobilised masses of test item in µg/g 605 689 647 59 9.2%
bioaccessibility in % 3.6 *10-3 4.1 *10-3 3.8 *10-3 3.5 *10-4 9.2%
Sample Al 1*
mobilised masses of test item in µg/g 25
bioaccessibility in % < 6.7 *10-5
* determined from the LOQ (0.25 mg/l) - Executive summary:
Findings and Results: Two tests with and two tests without the addition of full milk powder have been performed, as well as two blanks with and without milk powder. An aliquot of the remaining solutions then was thermically digested and resoluted in conc. HCl and water. The resulting solutions were measured via AAS for Mg and Al. Al determinations were below LOQ, only Mg showed values a little above the blanks in samples which were digested with the addition of milk powder. The mobilised masses of the measured elements and the bioaccessibilities are given in tabular form.
mobilised masses, bioaccessibility of Mg (Samples without addition of milk powder)
Sample Mg
1
2
Mean
sd
RSD
mobilised masses of test item in µg/g
82.5
427
254
244
96%
bioaccessibility in %
4.9*10-4
2.5 *10-3
1.5 *10-3
1.4 *10-3
96%
mobilised masses, bioaccessibility of Mg (Samples with addition of milk powder)
Sample Mg
3
4
Mean
sd
RSD
mobilised masses of test item in µg/g
605
689
647
59
9.2%
bioaccessibility in %
3.6 *10-3
4.1 *10-3
3.8 *10-3
3.5 *10-4
9.2%
mobilised masses, bioaccessibility of Al (calculated maximum)
Sample Al
Determined from LOQ
Calculated from Blank 1
Calculated from Blank 2
mobilised mass of test item in µg/g
< 25
< 12870
< 13458
bioaccessibility in %
< 6.7 *10-5
< 0.034
< 0.036
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