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Diss Factsheets
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EC number: 241-034-8 | CAS number: 16961-83-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published, guideline-comparable study
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenicity of cosmetics ingredients licensed by the European Communities
- Author:
- Gocke E, King MT, Eckhardt K & Wid D
- Year:
- 1 981
- Bibliographic source:
- Mutat Res 90:91-109
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- : small group size
- GLP compliance:
- no
- Remarks:
- : older published study
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Sodium hexafluorosilicate
- IUPAC Name:
- Sodium hexafluorosilicate
- Details on test material:
- Sodium hexafluorosilicate (Fisher Scientific)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- Two exposures at 0 and 24 hours.
- Frequency of treatment:
- Animals were dosed at 0 and 24 hours.
- Post exposure period:
- Bone marrow smears were prepared at 30 hours.
Doses / concentrations
- Dose / conc.:
- 37.6 other: mg/kg bw actual
- No. of animals per sex per dose:
- 2/sex
- Control animals:
- yes
Examinations
- Tissues and cell types examined:
- Bone marrow erythrocytes
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
Any other information on results incl. tables
No deaths occurred; signs of toxicity are not reported. The proportion of micronucleated PCEs in treated animals is reported to be 2.0/1000, compared to 2.2/1000 in controls. No evidence of mutagencitity was seen under the conditions of this assay.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
No evidence of mutagencitity was seen under the conditions of this assay. - Executive summary:
The genotoxicity of sodium hexafluorosilicate was investigated in a bone marrow micronucleus assay in NMRI mice. Animals (2/sex) were administered two intraperitoneal injections of the test substance at 37.6 mg/kg bw. No evidence of genotoxicity was seen in this study.
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