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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-146-2 | CAS number: 1306-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: other: chromosome aberration and sister chromatid exchanges
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable with restriction. Not according to GLP nor to specific test guidelines.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of fetal calf serum on the cadmium clastogenicity
- Author:
- Wang TC and Lee ML
- Year:
- 2 001
- Bibliographic source:
- Mutat Res 498: 79-87
Materials and methods
- Principles of method if other than guideline:
- CA:
-incubation time: 20 hours
-number of cells observed: 100 metaphases per culture
-staining: 3% Giemsa
SCE:
-incubation time: 24 hours
-number of cells observed: 50 metaphases per culture
-staining: fluorescence dye 33258 Hoechst plus Giemsa - GLP compliance:
- not specified
- Type of assay:
- other: in vitro mammalian chromosome aberrations test and sister chromatid exchange assay in mammalian cells
Test material
- Reference substance name:
- Cadmium carbonate
- EC Number:
- 208-168-9
- EC Name:
- Cadmium carbonate
- Cas Number:
- 513-78-0
- IUPAC Name:
- cadmium carbonate
- Details on test material:
- name of test substance: cadmium carbonate (FERAK, Berlin, Germany)
Constituent 1
Method
- Target gene:
- not applicable
Species / strain
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Details on mammalian cell type (if applicable):
- - Type and identity of media: McCoy 5A media + 10%FCS, sodium bicarbonate and antibiotics
- Additional strain / cell type characteristics:
- other: CHO cells were recloned for its karyotype stability and designated as CHO-W8 strain
- Metabolic activation:
- not applicable
- Metabolic activation system:
- not applicable
- Test concentrations with justification for top dose:
- CA: 0, 12.5, 25.0, 50.0, 100.0 µM
SCE: 0, 13.0, 25.0, 50.0, 100.0 µM - Vehicle / solvent:
- H2O
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- no
- Positive control substance:
- no
- Remarks:
- none
- Details on test system and experimental conditions:
- none
- Evaluation criteria:
- no information
- Statistics:
- not reported
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- not applicable
- Genotoxicity:
- other: CA (positive) and SCE (negative)
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not specified
- Additional information on results:
- none
- Remarks on result:
- other: strain/cell type: CHO cells
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: CA: positive and SCE: negative
This study reported that CA in Chinese hamster ovary (CHO-W8) were observed following cadmium carbonate treatment. Cadmium carbonate did not induce significant SCE at the same dose level that yielded significant chromosome aberrations. - Executive summary:
Wang and Lee (2001) treated Chinese hamster ovary (CHO-W8) cells with cadmium carbonate and found no induction of
SCE at the same dose level that yielded significant chromosome aberrations.
In this study 6 cadmium compounds were tested: cadmium acetate, cadmium carbonate, cadmium chloride, cadmium nitrate, cadmium oxide and cadmium sulfate. Cadmium nitrate, carbonate and oxide induced significant chromosome aberration, while the other three cadmium compounds gave negative results. All 6 cadmium compounds did not induce significant SCE
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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