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EC number: 220-688-8 | CAS number: 2867-47-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The subacute inhalation toxicity of 109 industrial chemicals
- Author:
- Gage JC
- Year:
- 1 970
- Bibliographic source:
- Brit. J. Industr. Med., 27, 1-18
- Reference Type:
- publication
- Title:
- Gage J.C., Brit. J. Industr. Med., 27, 1-18, 1970
- Author:
- Gage JC
- Year:
- 2 003
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Short-term vapor inhalation toxicity was studied in rats with a constant flow pump for 3 wks, 5 d/w, 6 h/d.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Details on test material:
- Purity not specified, but commercial grade assumed.
Constituent 1
- Specific details on test material used for the study:
- TEST MATERIAL:
- Name of test material: 2-Dimethylaminoethyl methacrylate
Test animals
- Species:
- rat
- Strain:
- other: Alderly Park SPF
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 700 g
- Diet: ad libitum except during exposures
- Water: ad libitum except during exposures
Administration / exposure
- Route of administration:
- other: inhalation: vapour at 100 ppm, possibly mist at 250 ppm
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Rats were exposed in a chamber described elsewhere (Gage, 1959); usually the inner Perspex chamber of that design was replaced by a glass cylinder, 30 cm diameter and 25 cm high.
- Method of conditioning air: The air used for the atmospheres was filtered, dried to a relative humidity of less than 10%, and supplied at a line pressure of 1 atm (1.013x10E+5 NmE-2).
- Method of atmosphere generation: A vapour concentration by injecting a liquid at a known rate into a metered stream of air by means of a controlled fluid-feed atomizer (Gage, 1953). - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 3 weeks
- Frequency of treatment:
- 6 hrs/day, 5 days/week
Doses / concentrationsopen allclose all
- Dose / conc.:
- 100 ppm (nominal)
- Dose / conc.:
- 250 ppm (nominal)
- No. of animals per sex per dose:
- 4
- Control animals:
- other: At intervals of about two months, batches of control rats were maintained in a chamber for the exposure period, in order to check the characteristics of the colony.
- Details on study design:
- - Design of the experiments: Alderley Park specific-pathogen-free rats with an average weight of 700 g were used in nlost of these experirnents. They were maintained in the exposure chamber for periods of up to 6 hours, and between repeated daily exposures they were returned to their cages where food and water were freely available. In the initial experiments the concentrations were selected to produce, if possible, acute effects after short exposures. Thereafter the exposure period was extended and the concentration lowered until the animals could survive 6-hour exposures, five days a week for up to four weeks. With liquids, the vapour pressure limited the range of concentrations which could be tested in these acute and subacute
experiments.
If at any stage effects were observed which could be attributed to the exposure, the experiment was repeated with progressively lower concentrations until a concentration was reached which was without effects on the animals.
Examinations
- Observations and examinations performed and frequency:
- The rats were weighed each morning, and their conditions and behaviour were recorded throughout the exposure period. Urine was collected overnight after the last exposure day for biochemical tests. The animals were left overnight with food and drink. On the following day the rats were anaesthetized with halothane and partially exsanguinated by heart puncture for haematological tests.
- Sacrifice and pathology:
- One day after the last exposure day rats were anaesthetized with halothane and partially exsanguinated by heart puncture for haematological tests. After a gross examination of the organs, the lungs were inflated with formol-saline and immersed in the same fixative. The following organs were also taken for microscopical examination after fixation in formol-corrosive: lungs, liver,kidneys, spleen, and adrenals; and occasionally heart, jejunum, ileum, and thymus.
Results and discussion
Results of examinations
- Details on results:
- At 250 ppm: Nose and eye irritation, rapid breathing, weight gain low and irregular. No change of haematological and clinical parameters in blood and urine. No pathological (macroscopical and microscopical) effects on organs were observed.
At 100 ppm: No toxic effects were observed.
Effect levels
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- 100 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: nose and eye irritation
- Dose descriptor:
- LOAEC
- Effect level:
- 250 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: nose and eye irritation
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The NOAEC for repeated inhalation toxicity is considered to be 100 ppm (643 mg/m³).
- Executive summary:
Short-term vapor inhalation toxicity was studied in rats with a constant flow pump for 3 wks, 5 d/w, 6 h/d. At 250 ppm (1608 mg/m³), nose and eye irritation and labored breathing were observed. The body weight gain was slow. There were no changes in the hematological parameters. No pathological (macroscopical and microscopical) effects on organs were observed. At 100 ppm (643 mg/m³), no toxic effects were observed.
Conclusion: The NOAEC for repeated inhalation toxicity is considered to be 100 ppm (643 mg/m³).
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