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Diss Factsheets
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EC number: 203-808-3 | CAS number: 110-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
As indicated in the EU RAR (2005):
Groups of 15 MRC rats per sex were given 0.025% of piperazine in the drinking water (20 -25 mg/kg/day), 5 days/week, during 75 weeks after which the animals were kept until death and subjected to complete pathological examination. The dosed animals did not exhibit any increase of tumours in comparison with 15 male and 15 female controls (Garcia and Lijinsky, 1973).
When administered at 6.25 g/kg in the feed (about 938 mg/kg/day6) for 28 weeks and sacrificed at 40 weeks, it failed to induce any significant increase in the incidence of lung adenomas in groups of 40 Swiss mice per sex in comparison with controls (80 animals per sex) (Greenblatt et al., 1971). It is not possible to judge the extent of histopathologica examination performed upon autopsy, but in addition to lung adenomas, lymphomas, liver,
mammary glands, as well as sex organs seem to have undergone examination. The only significant finding was a reduction in the number of malignant lymphomas in the piperazine treated animals.
Similar treatment of strain A mice with piperazine at 6.3 (938 mg/kg/day), or 18.8 g/kg (2,820 mg/kg/day) for 25 weeks, followed by a 13 weeks follow up post dosing, did not significantly increase the number of animals with lung adenomas. No histopathological analysis of other organs seems to have been performed (Greenblatt and Mirvish, 1973).
Available carcinogenicity studies with piperazine are scantily reported and do not meet present days' standards in most respects.
Key value for chemical safety assessment
Justification for classification or non-classification
Conclusion in EU RAR (2005):
Although there are no solid indications of a carcinogenic effect of piperazine, either in animal studies, or from the investigation in humans, the supporting database is insufficient to permit definite conclusions. However, in view of lack of genotoxic action, it appears unlikely that piperazine poses a carcinogenic risk.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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