Registration Dossier
Registration Dossier
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EC number: 701-480-0 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The following information is taken into account for any hazard / risk / bioaccumulation assessment:
The UVCB bioaccumulation is driven by the bioaccumulation of the individual UVCB constituents. Bioaccumulation on the individual UVCB constituents is reported in individual IUCLID section 5.3 summaries, if relevant.
Metals like Cu, Zn are essential and well regulated in all living organisms and therefore the bio accumulative criterion is not applicable. Data for copper (Cu RA, 2008 and Cu CSR, 2010) demonstrate that copper is not biomagnified in the aquatic and terrestrial ecosystems and that there is no issue for secondary poisoning of copper.The copper Risk Assessment Report (2008) and REACH Chemical Safety Report (2010) have provided detailed information on (1) the essentiality of copper; (2) the homeostatic control of copper; (3) the mechanisms of action of copper ions; (4) the comparison between copper toxicity from dietary versus waterborne exposures. From this information, it has been concluded that the bio-accumulation criterion does not apply to the essential element copper. Similarly, in the zinc risk assessment and chemical safety report (2010), it has been concluded that the bio-accumulation criterion does not apply to the essential element zinc.
Secondary poisoning is however considered relevant for lead, nickel and cadmium, based on their known bioaccumulation potential.The bio-accumulation potential of lead and nickel has been assessed in the lead and nickel risk assessments (2007), REACH Chemical Safety Report (2010) and under the EU Water Framework Directive. These assessments concluded that both lead and nickel are not bio- magnified and do not pose a secondary poisoning concern.”Secondary poisoning of lead, nickel and cadmium contained in the copper slag is further taken into account in the environmental exposure assessment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
